IN BRIEF:

Centella asiatica (L.) Urban is a traditional medicinal plant (“Medhya-Rasayana” herb in Ayurvedic medicine) and a potent, non-carcinogenic telomerase activator. The longer our telomeres, the biologically younger our cells are, and the better our health. Aging is closely related to telomere length.

Centella extract is a potent telomerase (“fountain of youth enzyme) – activator. It leads to a significant extension of telomeres and an increase in telomerase activity (Nobel Prize 2009). Centella extract shows an 8.8-fold increase in telomerase activity.

Centella extract is not a carcinogenic agent.

Centella asiatica and its triterpenoids have a range of pharmacological effects and health benefits.

Only the leaves of Centella asiatica contain a high content of medically effective substances (Centella leaf extract).

 

Centella as a Traditional Medicinal Plant

Medicinal plants have proven to be a source of molecules with therapeutic potential in the past and present.

The well-known medicinal plant Centella asiatica (L.) Urban is an Ayurvedic and traditional Chinese medicine used to treat various health issues and consumed as edible greens in regular diets.

Centella asiatica (L.) Urban is a medicinal herb from the Apiaceae family that has been utilized since prehistoric times (Kartnig, 1988). It is known by various names such as Indian pennywort, wild violet, tiger herb, among others.

 

Botanical Safety

Centella asiatica (L.) Urban is classified as a Class 1 herb (a herb that can be safely consumed when used properly) in the Botanical Safety Handbook.

For example, Centella asiatica (L.) Urban is listed in monographs of the following countries: China (Chinese Pharmacopoeia: Centella) (Tang and Eisenbrand, 1972), Germany (HAB 1: Centella), United Kingdom (British Herbal Pharmacopoeia: Centella; Martindale, The Extra Pharmacopoeia: 1600-d Centella), India (Herba Ind P 53: Centella).

 

Centella Leaf Extract is a potent Telomerase (“Fountain of Youth Enzyme) – Activator.

The solution to one of biology’s great mysteries has been found: How are chromosomes replicated and protected from degradation during cell division? The answer lies in the chromosome ends—the telomeres—and the enzyme that forms them—the telomerase.

Significant Telomere Extension

Telomeres are short nucleotide sequences at the end of chromosomes that contain their genes.

Researchers observed a significant extension of telomeres with the intake of Centella extract. These results suggest that Centella extract could be used for the treatment of age-related diseases, and Centella asiatica extracts have been shown to have calming, antidepressant, antispasmodic, and analgesic effects.

Source: Karsono AH, Tandrasasmita OM, Berlian G, Tjandrawinata RR. Potential Antiaging Effects of DLBS1649, a Centella asiatica Bioactive Extract. J Exp Pharmacol. 2021 Aug 11;13:781-795. doi: 10.2147/JEP.S299547. PMID: 34413686; PMCID: PMC8369046.

The shorter our telomeres, the biologically older we become.

But the opposite is also true:

The longer our telomeres, the biologically younger our cells are and the better our health.

 

Increase in Telomerase Activity

Some studies have shown that telomerase activators have the potential to maintain or even lengthen telomeres, theoretically leading to a slowing down of the aging process.

Centella asiatica extract leads to an almost nine-fold increase in telomerase activity compared to untreated cells and is thus the strongest telomerase activator among all other dietary supplements available in the market.

In a recent study, 3700 twins aged between 70 and 82 years were examined. It was found that those with a shorter average telomere length were more likely to exhibit deterioration in various health indicators. These include lung function, memory, and walking speed.

 

The “fountain of youth enzyme,”

a world sensation!

The “fountain of youth enzyme” was first discovered just before Christmas 1984 in the ciliate “Tetrahymena.”

The discoverers are considered to be the two molecular biologists Elizabeth Blackburn and Carol Greider. In 2009, the two scientists were awarded the Paul Ehrlich Prize as well as the Nobel Prize in Physiology or Medicine.

Source: Greider CW, Blackburn EH. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell. 1985 Dec;43(2 Pt 1):405-13. doi: 10.1016/0092-8674(85)90170-9. PMID: 3907856.

 

Telomeres and Aging

Telomeres are specialized structures at the ends of chromosomes that protect them from degradation.

As we age, our telomeres naturally shorten due to the cellular replication process. When telomeres become too short, cells can no longer divide, leading to cellular senescence or death.

Aging is closely related to telomere length, and maintaining telomere length is associated with better health and longevity.

 

Telomerase and Telomere Length

Telomerase is an enzyme that adds repetitive nucleotide sequences to the ends of chromosomes, counteracting the natural shortening of telomeres that occurs with each cell division.

Telomerase activity is crucial for maintaining telomere length and preventing cellular aging.

Telomerase activation has been proposed as a potential strategy for slowing down the aging process and extending lifespan.

 

Centella asiatica Extract and Telomerase Activation

Centella asiatica extract has been identified as a potent telomerase activator, capable of significantly increasing telomerase activity in cells.

Telomerase activation by Centella asiatica extract can lead to elongation of telomeres and potentially slow down the aging process.

The use of Centella asiatica extract as a telomerase activator may have therapeutic implications for age-related diseases and promoting healthy aging.

Furthermore, Centella asiatica extract has been shown to have various pharmacological effects and health benefits, making it a promising candidate for further research and development in the field of anti-aging medicine.

 

Centella asiatica: A Promising Anti-Aging Agent

In summary, Centella asiatica extract is a promising anti-aging agent due to its ability to activate telomerase and potentially extend telomeres.

Centella asiatica extract shows great potential for promoting healthy aging and longevity.

As with any supplement or medication, it is essential to consult with a healthcare professional before incorporating Centella asiatica extract into your routine, especially if you have any underlying health conditions or are taking other medications.

Increased Telomerase Activity influences brain health

Some studies have shown that telomerase activators have the potential to maintain or even lengthen telomeres, theoretically leading to a slowing of the aging process.

Telomere Length and Its Physical Impact on the Brain Telomere length can influence brain health. Shorter telomeres are associated with cognitive decline and increased risk of neurodegenerative diseases.

Implications of Centella Leaf Extract on Cells Aging is closely related to telomere length. DNA maintains absolute telomere length, prevents a decrease in telomerase protein levels and TERT expression, leads to increased expression of cell cycle genes like c-Myc expression, and is not a tumorigenic agent.

 

Centella asiatica and Its Pharmacological Effects

 

Centella asiatica has a wide range of pharmacological effects, including neuroprotective, cardioprotective, hepatoprotective, wound healing, anti-inflammatory, antioxidant, and antidepressant properties.

Centella asiatica in Ayurvedic Medicine Centella asiatica (Mandukaparni) has been used in Ayurvedic medicine in India for almost 2000 years for its neuropharmacological properties. Centella asiatica leaf extract accelerates neural differentiation in hippocampal neurons, improves dendritic and axonal morphology, and facilitates synapse formation.

Why Centella Leaf Extract?

Only the leaves of Centella asiatica contain high levels of alkaloids, flavonoids, terpenoids, and saponins as medically active components.

Centella asiatica accumulates large amounts of pentacyclic triterpenoid saponins, collectively called centelloids. These triterpenes include Asiaticoside, Centelloside, Madecassoside, Brahmoside, Brahminoside, Thankuniside, Sceffoleoside, Centellose, Asiatic acid, Brahminic acid, Centellinic acid, and Madecassic acid.

The Role of Centelloids and Their Effects Centella asiatica exhibits a variety of pharmacological activities due to its primary active constituents, Asiaticoside and Madecassoside, and their respective aglycones (sapogenins), Asiatic acid, and Madecassic acid.

 

In summary

Centella asiatica is a remarkable plant with various medicinal properties, particularly in promoting brain health, wound healing, and overall longevity. Its extract has shown promising effects on telomere length and telomerase activity, suggesting potential anti-aging benefits.