{"id":2388,"date":"2017-11-24T12:34:44","date_gmt":"2017-11-24T11:34:44","guid":{"rendered":"https:\/\/nugenis.eu\/?page_id=2388\/"},"modified":"2026-06-02T18:31:58","modified_gmt":"2026-06-02T16:31:58","slug":"eduard-rappold","status":"publish","type":"page","link":"https:\/\/nugenis.eu\/en\/eduard-rappold\/","title":{"rendered":"Dr. Eduard Rappold, MSc"},"content":{"rendered":"\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-n1o0r8-bff9907fa41a382633ddd3e7089d8b50\">\n.avia-section.av-n1o0r8-bff9907fa41a382633ddd3e7089d8b50{\nbackground-repeat:no-repeat;\nbackground-image:url(https:\/\/nugenis.eu\/wp-content\/uploads\/2016\/08\/Nugenis_home2-1-1500x430.jpg);\nbackground-position:0% 0%;\nbackground-attachment:scroll;\n}\n.avia-section.av-n1o0r8-bff9907fa41a382633ddd3e7089d8b50 .av-section-color-overlay{\nopacity:0.5;\nbackground-color:#000000;\nbackground-image:url(https:\/\/nugenis.eu\/wp-content\/themes\/nugenis\/images\/background-images\/grain_top.png);\nbackground-repeat:repeat;\n}\n<\/style>\n<div id='msc'  class='avia-section av-n1o0r8-bff9907fa41a382633ddd3e7089d8b50 main_color avia-section-default avia-no-shadow  avia-builder-el-0  el_before_av_section  avia-builder-el-first  avia-full-stretch avia-bg-style-scroll av-section-color-overlay-active av-minimum-height av-minimum-height-25 av-height-25  container_wrap sidebar_right'  data-section-bg-repeat='stretch' data-av_minimum_height_pc='25' data-av_min_height_opt='25'><div class=\"av-section-color-overlay-wrap\"><div class=\"av-section-color-overlay\"><\/div><a href='#next-section' title='' class='scroll-down-link  avia-svg-icon avia-font-svg_entypo-fontello' data-av_svg_icon='down-open-mini' data-av_iconset='svg_entypo-fontello'><svg version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"15\" height=\"32\" viewBox=\"0 0 15 32\" preserveAspectRatio=\"xMidYMid meet\" aria-labelledby='av-svg-title-1' aria-describedby='av-svg-desc-1' role=\"graphics-symbol\" aria-hidden=\"true\">\n<title id='av-svg-title-1'>Scroll to next section<\/title>\n<desc id='av-svg-desc-1'>Scroll to next section<\/desc>\n<path d=\"M12.96 12.16q0.704-0.832 1.536 0 0.832 0.704 0 1.536l-6.272 6.144q-0.704 0.704-1.536 0l-6.272-6.144q-0.832-0.832 0-1.536 0.768-0.768 1.6 0l5.44 4.992z\"><\/path>\n<\/svg><\/a><div class='container av-section-cont-open' ><main  role=\"main\" itemprop=\"mainContentOfPage\"  class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-2388'><div class='entry-content-wrapper clearfix'>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-l4v638-bd0739d79df98b34a7309b279ad317d0\">\n#top .av-special-heading.av-l4v638-bd0739d79df98b34a7309b279ad317d0{\npadding-bottom:10px;\ncolor:#ffffff;\n}\nbody .av-special-heading.av-l4v638-bd0739d79df98b34a7309b279ad317d0 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-l4v638-bd0739d79df98b34a7309b279ad317d0 .special-heading-inner-border{\nborder-color:#ffffff;\n}\n.av-special-heading.av-l4v638-bd0739d79df98b34a7309b279ad317d0 .av-subheading{\nfont-size:20px;\n}\n<\/style>\n<div  class='av-special-heading av-l4v638-bd0739d79df98b34a7309b279ad317d0 av-special-heading-h1 custom-color-heading blockquote modern-quote modern-centered  avia-builder-el-1  el_before_av_hr  avia-builder-el-first '><h1 class='av-special-heading-tag '  itemprop=\"headline\"  >NUGENIS &#8211; DR EDUARD RAPPOLD, MSc<\/h1><div class='av_custom_color av-subheading av-subheading_below'><p>Immersed in Alzheimer-Research<\/p>\n<\/div><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div>\n<div  class='hr av-iful2c-a1bb09e1a88ccb2bbcce6c21f7d758fa hr-short  avia-builder-el-2  el_after_av_heading  avia-builder-el-last  hr-center'><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n\n<\/div><\/div><\/main><!-- close content main element --><\/div><\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-hf5n1w-694b711e013af6f525187bcab50a0741\">\n.avia-section.av-hf5n1w-694b711e013af6f525187bcab50a0741{\nbackground-color:#ffffff;\nbackground-image:unset;\n}\n<\/style>\n<div id='av_section_2'  class='avia-section av-hf5n1w-694b711e013af6f525187bcab50a0741 main_color avia-section-default avia-no-border-styling  avia-builder-el-3  el_after_av_section  el_before_av_section  avia-bg-style-scroll container_wrap sidebar_right'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-2388'><div class='entry-content-wrapper clearfix'>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-g3iqxw-f3c272bbf632cc2da9bcfd8314aea11b\">\n.flex_column.av-g3iqxw-f3c272bbf632cc2da9bcfd8314aea11b{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-g3iqxw-f3c272bbf632cc2da9bcfd8314aea11b av_two_fifth  avia-builder-el-4  el_before_av_three_fifth  avia-builder-el-first  first flex_column_div av-animated-generic fade-in av-zero-column-padding  '     ><p><section  class='avia-team-member av-enalr8-16a27a2d75f7ab74fb3c7d956cdb187d  avia-builder-el-5  el_before_av_button  avia-builder-el-first '  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/Person\" ><div class=\"team-img-container\"><img decoding=\"async\" fetchpriority=\"high\" class='wp-image-189 avia-img-lazy-loading-not-189 avia_image avia_image_team' src=\"https:\/\/nugenis.eu\/wp-content\/uploads\/2016\/08\/foto-edo.jpg\" alt='Dr. med. Eduard Rappold, MSc'  itemprop=\"image\"   height=\"772\" width=\"541\" srcset=\"https:\/\/nugenis.eu\/wp-content\/uploads\/2016\/08\/foto-edo.jpg 541w, https:\/\/nugenis.eu\/wp-content\/uploads\/2016\/08\/foto-edo-450x642.jpg 450w, https:\/\/nugenis.eu\/wp-content\/uploads\/2016\/08\/foto-edo-210x300.jpg 210w, https:\/\/nugenis.eu\/wp-content\/uploads\/2016\/08\/foto-edo-494x705.jpg 494w\" sizes=\"(max-width: 541px) 100vw, 541px\" \/><\/div><h3 class='team-member-name '  itemprop=\"name\" >Dr. med. Eduard Rappold, MSc<\/h3><div class='team-member-job-title '  itemprop=\"jobTitle\" >Scientist and medical practitioner <\/div><span class='hidden team-member-affiliation'  itemprop=\"affiliation\" >NUGENIS<\/span><\/section><br \/>\n<div  class='avia-button-wrap av-cs1oz8-52bec70d2ec7f597f5119e4fe508e8f5-wrap avia-button-center  avia-builder-el-6  el_after_av_team_member  el_before_av_button '><a href='https:\/\/www.facebook.com\/nugenis'  class='avia-button av-cs1oz8-52bec70d2ec7f597f5119e4fe508e8f5 av-link-btn avia-icon_select-yes-left-icon avia-size-small avia-position-center avia-color-theme-color'  target=\"_blank\"  rel=\"noopener noreferrer\"  aria-label=\"News\"><span class='avia_button_icon avia_button_icon_left avia-iconfont avia-font-entypo-fontello' data-av_icon='\ue8f5' data-av_iconfont='entypo-fontello' ><\/span><span class='avia_iconbox_title' >News<\/span><\/a><\/div><br \/>\n<div  class='avia-button-wrap av-a9pld0-bb17934384789f35058b9a42a3a6b8d7-wrap avia-button-center  avia-builder-el-7  el_after_av_button  avia-builder-el-last '><a href='&#x6d;&#97;i&#x6c;&#116;o&#x3a;&#101;d&#x75;&#97;r&#x64;&#46;r&#x61;&#112;p&#x6f;&#108;d&#x40;&#110;u&#x67;&#101;n&#x69;&#115;&#46;&#x65;&#117;'  class='avia-button av-a9pld0-bb17934384789f35058b9a42a3a6b8d7 av-link-btn avia-icon_select-yes-left-icon avia-size-small avia-position-center avia-color-theme-color'  target=\"_blank\"  rel=\"noopener noreferrer\"  aria-label=\"Mail\"><span class='avia_button_icon avia_button_icon_left avia-iconfont avia-font-entypo-fontello' data-av_icon='\ue805' data-av_iconfont='entypo-fontello' ><\/span><span class='avia_iconbox_title' >Mail<\/span><\/a><\/div><\/p><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-8n9wc4-98a96e32c724acaab561c518dff60b3b\">\n.flex_column.av-8n9wc4-98a96e32c724acaab561c518dff60b3b{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-8n9wc4-98a96e32c724acaab561c518dff60b3b av_three_fifth  avia-builder-el-8  el_after_av_two_fifth  avia-builder-el-last  flex_column_div av-animated-generic fade-in av-zero-column-padding  '     ><section  class='av_textblock_section av-85zgxg-367587b389af764abf5b939682a4bf6c '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p data-start=\"74\" data-end=\"357\"><strong data-start=\"74\" data-end=\"92\">Eduard Rappold<\/strong> is a physician, researcher, and author specializing in epigenetics, prevention, and healthy aging.<br data-start=\"191\" data-end=\"194\" \/>His work bridges scientific insights from Alzheimer\u2019s research, mitochondrial biology, and stress regulation with practical strategies to support long-term health.<\/p>\n<p data-start=\"359\" data-end=\"473\">As the founder of NUGENIS, his mission is clear:<br data-start=\"407\" data-end=\"410\" \/>to understand biological regulation\u2014and to actively support it.<\/p>\n<p data-start=\"475\" data-end=\"729\">His approach is based on a central insight: health is not a matter of chance, but the result of modifiable processes at the cellular level.<br data-start=\"614\" data-end=\"617\" \/>At the core are epigenetic mechanisms that can be influenced by nutrition, lifestyle, and environmental factors.<\/p>\n<p data-start=\"731\" data-end=\"907\">Through <strong data-start=\"739\" data-end=\"756\">Epigenetik.at<\/strong>, he provides a platform that translates complex science into clear, actionable knowledge\u2014offering new perspectives on health, disease, and prevention.<\/p>\n<\/div><\/section><\/div>\n\n<\/div><\/div><\/div><!-- close content main div --><\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-6i5mck-f691c4002ba28c14916cb6e304daa195\">\n.avia-section.av-6i5mck-f691c4002ba28c14916cb6e304daa195{\nbackground-color:#ffffff;\nbackground-image:unset;\n}\n<\/style>\n<div id='av_section_3'  class='avia-section av-6i5mck-f691c4002ba28c14916cb6e304daa195 main_color avia-section-default avia-no-border-styling  avia-builder-el-10  el_after_av_section  avia-builder-el-last  avia-bg-style-scroll container_wrap sidebar_right'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-2388'><div class='entry-content-wrapper clearfix'>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-4iuj84-1ce073108ebac1927e7970eff9aad3d3\">\n#top .av-special-heading.av-4iuj84-1ce073108ebac1927e7970eff9aad3d3{\npadding-bottom:10px;\n}\nbody .av-special-heading.av-4iuj84-1ce073108ebac1927e7970eff9aad3d3 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-4iuj84-1ce073108ebac1927e7970eff9aad3d3 .av-subheading{\nfont-size:15px;\n}\n<\/style>\n<div  class='av-special-heading av-4iuj84-1ce073108ebac1927e7970eff9aad3d3 av-special-heading-h3 blockquote modern-quote  avia-builder-el-11  el_before_av_one_full  avia-builder-el-first '><h3 class='av-special-heading-tag '  itemprop=\"headline\"  >Selected publications<\/h3><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-2nvwtg-d4badaca413dc721ffd36e53b58e3501\">\n.flex_column.av-2nvwtg-d4badaca413dc721ffd36e53b58e3501{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-2nvwtg-d4badaca413dc721ffd36e53b58e3501 av_one_full  avia-builder-el-12  el_after_av_heading  avia-builder-el-last  first flex_column_div av-animated-generic fade-in av-zero-column-padding  '     ><section  class='av_textblock_section av-l9bgx3wd-f52f4b567a621b79ca363c6c86e187dd '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p><strong>Therapeutics That Can Potentially Replicate or Augment the Anti-Aging Effects of Physical Exercise<\/strong><br \/>\nAdriana De Sousa Lages, Valentim Lopes, Jo\u00e3o Horta, Jo\u00e3o Espregueira-Mendes, Renato Andrade and Alexandre Rebelo-Marques [<a href=\"https:\/\/nugenis.eu\/wp-content\/uploads\/2022\/10\/kathi-wissenschaftliche-arbeit-de-sousa-lages-2022-anti-aging-sports-spd.pdf\">Read<\/a>]<\/p>\n<p><strong>Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer\u2019s disease mouse model<\/strong><br \/>\nKiara Freitag, Nele Sterczyk, Sarah Wendlinger, Benedikt Obermayer, Julia Schulz, Vadim Farztdinov, Michael M\u00fclleder, Markus Ralser, Judith Houtman, Lara Fleck, Caroline Braeuning, Roberto Sansevrin, Christian Hoffmann, Dragomir Milovanovic, Stephan J. Sigrist, Thomas Conrad, Dieter Beule, Frank L. Heppner, and Marina Jendrach [<a href=\"https:\/\/nugenis.eu\/wp-content\/uploads\/2022\/10\/kathi-wissenschaftliche-arbeit-freitag-2022-alzheimer-spd.pdf\">Read<\/a>]<\/p>\n<p><strong>Spermidine-mediated hypusination of translation factor EIF5A improves mitochondrial fatty acid oxidation and prevents non-alcoholic steatohepatitis progression<\/strong><br \/>\nJin Zhou, Jeremy Pang, Madhulika Tripathi, Jia Pei H,Anissa Anindya Widjaja, Shamini Guna Shekeran, Stuart Alexander Cook, Ayako Suzuki, Anna Mae Diehl ,Enrico Petretto , Brijesh Kumar Singh1 &amp; Paul Michael Yen [<a href=\"https:\/\/nugenis.eu\/wp-content\/uploads\/2022\/10\/kathi-wissenschaftliche-arbeit-zhou-2022-spermidine-steatohepatitis.pdf\">Read<\/a>]<\/p>\n<p style=\"text-align: justify;\"><strong>Gender-related increase of tropomyosin-1 abundance in platelets of Alzheimer&#8217;s disease and mild cognitive impairment patients<\/strong><br \/>\nReumiller, CM., Schmidt, GJ., Dharami, I., Umlauf, E., Rappold, E., Zellner, M.<br \/>\nJournal of Proteomics (2017) (epub ahead of print) [<a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S1874391917304414?via%3Dihub\" target=\"_blank\" rel=\"noopener\">Read<\/a>]<\/p>\n<p style=\"text-align: justify;\"><strong>Careful neuropsychological testing reveals a novel genetic marker, GSTO1*C, linked to the pre-stage of Alzheimer&#8217;s disease<\/strong><br \/>\nUmlauf,E., Rappold, E., Schiller, B., Fuchs, P., Rainer, M., Wolf, B., Zellner, M.<br \/>\nOncotarget 7 (26) (2016) [<a href=\"http:\/\/www.impactjournals.com\/oncotarget\/index.php?journal=oncotarget&amp;page=article&amp;op=download&amp;path%5B%5D=9773&amp;path%5B%5D=30639\" target=\"_blank\" rel=\"noopener\">Read<\/a>]<\/p>\n<p style=\"text-align: justify;\"><strong>A platelet protein biochip rapidly detects an Alzheimer&#8217;s disease-specific phenotype<\/strong><br \/>\nVeitinger, M., Oehler, R., Umlauf, E., Baumgartner, R., Schmidt, G., Gerner, Ch., Babeluk, R., Attems, J., Mitulovi\u0107, G., Rappold, E., Lamont, J., Zellner, M.<br \/>\nActa Neuropathologica 128(5) (2014) [<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4201753\" target=\"_blank\" rel=\"noopener\">Read<\/a>]<\/p>\n<p style=\"text-align: justify;\"><strong>Impact of Ademetionine Disulfate Tosylate \/Vitamin B12 therapy on cognition in Alzheimer\u2019s Disease and related<\/strong> <strong>biomarkers<\/strong><br \/>\nRappold E.<br \/>\nMaster-These an der Donau-Universit\u00e4t Krems (2014)<\/p>\n<p style=\"text-align: justify;\"><strong>Identification and validation of platelet low biological variation proteins, superior to GAPDH, actin and tubulin, as tools in clinical proteomics<\/strong><br \/>\nBaumgartner, R., Umlauf, E., Veitinger, M., Guterres, S., Rappold, E., Babeluk, R., Mitulovi\u0107, G., Oehler, R., Zellner, M.<br \/>\nJournal of proteomics 94C:540-551 (2013) [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24284060\" target=\"_blank\" rel=\"noopener\">Read<\/a>]<\/p>\n<p style=\"text-align: justify;\"><strong>Comparative platelet proteome analysis reveals an increase of monoamine oxidase-B protein expression in Alzheimer&#8217;s disease but not in non-demented Parkinson&#8217;s disease patients<\/strong><br \/>\nZellner; M. , Baureder, M., Rappold, E., Bugert, P., Kotzailias, N., Babeluk, R., Baumgartner, R., Attems, J., Gerner, Ch., Jellinger, K., Roth, E., Oehler, R., Umlauf, E.\u00b7<br \/>\nJournal of proteomics 75(7):2080-92 (2012) [<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22270014\" target=\"_blank\" rel=\"noopener\">Read<\/a>]<\/p>\n<p style=\"text-align: justify;\"><strong>Langzeitern\u00e4hrungstherapie einer hochbetagten Seniorin. Positive Effekte durch die Gabe von Sondennahrung auf Basis von Lebensmittel<\/strong><br \/>\nRappold, E. \u00b7<br \/>\nfocus neurogeriatrie 3(1):16-20 (2009)<\/p>\n<p style=\"text-align: justify;\"><strong>Biological Variation of the Platelet Proteome in the Elderly Population and Its Implication for Biomarker Research<\/strong><br \/>\nWinkler, W., Zellner, M., Diestinger, M., Babeluk, R., Marchetti, M., Goll, A., Zehetmayer, S., Bauer, P., Rappold, E., Miller, I., Roth, E., Allmaier, G., Oehler, R. \u00b7<br \/>\nMolecular &amp; Cellular Proteomics 7(1):193-203 (2008) [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17962630\" target=\"_blank\" rel=\"noopener\">Read<\/a>]<\/p>\n<p style=\"text-align: justify;\"><strong>Aspekte der k\u00fcnstlichen Ern\u00e4hrung bei demenzkranken Patienten in der Geriatrie<\/strong><br \/>\nRappold, E., Kratochvila, H. G.<br \/>\nEthik in der Medizin 16(3):253-264 (2004)<\/p>\n<p style=\"text-align: justify;\"><strong>Downregulation of carnitine acyltransferases and organic cation transporter OCTN2 in mononuclear cells in healthy elderly and patients with myelodysplastic syndromes<\/strong><br \/>\nKarlic, H., Lohninger, G., Laschan, C., Lapin, A., B\u00f6hmer, F., Huemer, M., Guthann, E., Rappold, E., Pfeilst\u00f6cker, M.<br \/>\nJournal of Molecular Medicine 81(7):435-42 (2003) [<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12802501\" target=\"_blank\" rel=\"noopener\">Read<\/a>]<\/p>\n<p style=\"text-align: justify;\"><strong>Treatment of polymorphous light eruption with nicotinamide: a pilot study<\/strong><br \/>\nNeumann, R., Rappold, E., Pohl-Markl, H.<br \/>\nBritish Journal of Dermatology 115(1):77-80 (1986) [<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/2942169\">Read<\/a>]<\/p>\n<div class=\"qMYqUG_convSearchResultHighlightRoot\">\n<div class=\"\" data-turn-id-container=\"request-9bae5b7a-e1a1-4d7f-ab78-fae57a5c87b2-0\" data-is-intersecting=\"true\">\n<section class=\"text-token-text-primary w-full focus:outline-none has-data-writing-block:pointer-events-none &#091;&amp;:has(&#091;data-writing-block&#093;)&gt;*&#093;:pointer-events-auto R6Vx5W_threadScrollVars scroll-mb-&#091;calc(var(--scroll-root-safe-area-inset-bottom,0px)+var(--thread-response-height))&#093; scroll-mt-&#091;calc(var(--header-height)+min(200px,max(70px,20svh)))&#093;\" dir=\"auto\" data-turn-id=\"request-9bae5b7a-e1a1-4d7f-ab78-fae57a5c87b2-0\" data-turn-id-container=\"request-9bae5b7a-e1a1-4d7f-ab78-fae57a5c87b2-0\" data-testid=\"conversation-turn-86\" data-scroll-anchor=\"false\" data-turn=\"assistant\">\n<div class=\"text-base my-auto mx-auto pb-10 &#091;--thread-content-margin:var(--thread-content-margin-xs,calc(var(--spacing)*4))&#093; @w-sm\/main:&#091;--thread-content-margin:var(--thread-content-margin-sm,calc(var(--spacing)*6))&#093; @w-lg\/main:&#091;--thread-content-margin:var(--thread-content-margin-lg,calc(var(--spacing)*16))&#093; px-(--thread-content-margin)\">\n<div class=\"&#091;--thread-content-max-width:40rem&#093; @w-lg\/main:&#091;--thread-content-max-width:48rem&#093; mx-auto max-w-(--thread-content-max-width) flex-1 group\/turn-messages focus-visible:outline-hidden relative flex w-full min-w-0 flex-col agent-turn\">\n<div class=\"flex max-w-full flex-col gap-4 grow\">\n<div class=\"min-h-8 text-message relative flex w-full flex-col items-end gap-2 text-start break-words whitespace-normal outline-none keyboard-focused:focus-ring &#091;.text-message+&amp;&#093;:mt-1\" dir=\"auto\" tabindex=\"0\" data-message-author-role=\"assistant\" data-message-id=\"0fa41bb7-d59d-4e4b-bec4-eff64a690814\" data-message-model-slug=\"gpt-5-5\" data-turn-start-message=\"true\">\n<div class=\"flex w-full flex-col gap-1 empty:hidden\">\n<div class=\"markdown prose dark:prose-invert wrap-break-word w-full light markdown-new-styling\">\n<h3 data-start=\"0\" data-end=\"79\">The following bibliography documents the scientific foundations of epigenetics (2026)<\/h3>\n<p data-start=\"81\" data-end=\"334\" data-is-last-node=\"\" data-is-only-node=\"\">It includes key publications in molecular biology and epigenetics, clinical studies, translational research, as well as contributions from related disciplines such as neuroscience, metabolic biology, oncology, psychoneuroimmunology, and health sciences.<\/p>\n<p><strong>A<\/strong><\/p>\n<p><strong>Abdallah, C. G., et al.<\/strong> (2018).<br \/>\nKetamine\u2019s mechanism of action: A path to rapid-acting antidepressants.<br \/>\n<em>Depression and Anxiety, 35<\/em>, 104\u2013114.<br \/>\n<a href=\"https:\/\/doi.org\/10.1002\/da.22739\">https:\/\/doi.org\/10.1002\/da.22739<\/a><\/p>\n<p><strong>Aktan, F.<\/strong> (2004).<br \/>\niNOS-mediated nitric oxide production and inflammation.<br \/>\n<em>Life Sciences, 75<\/em>, 639\u2013653.<\/p>\n<p><strong>Albert, M. S., DeKosky, S. T., Dickson, D., Dubois, B., Feldman, H. H., Fox, N. C., Gamst, A., Holtzman, D. M., Jagust, W. J., Petersen, R. C., Snyder, P. J., Carrillo, M. C., Thies, B., &amp; Phelps, C. H.<\/strong> (2011). The diagnosis of mild cognitive impairment due to Alzheimer\u2019s disease. <em>Alzheimer\u2019s &amp; Dementia, 7<\/em>(3), 270\u2013279. https:\/\/doi.org\/10.1016\/j.jalz.2011.03.008<\/p>\n<p><strong>Alberts, B., Johnson, A., Lewis, J., Morgan, D., Raff, M., Roberts, K., &amp; Walter, P.<\/strong> (2015).<br \/>\n<em>Molecular biology of the cell<\/em> (6th ed.). Garland Science.<\/p>\n<p><strong>Allis, C. D., Jenuwein, T., &amp; Reinberg, D.<\/strong> (2015).<br \/>\n<em>Epigenetics<\/em> (2nd ed.). Cold Spring Harbor Laboratory Press.<\/p>\n<p><strong>Allis, C. D., &amp; Jenuwein, T.<\/strong> (2016).<br \/>\nEpigenetics in the twenty-first century.<br \/>\n<em>Cell, 167<\/em>(1), 13\u201327.<br \/>\n<a href=\"https:\/\/doi.org\/10.1016\/j.cell.2016.02.006\">https:\/\/doi.org\/10.1016\/j.cell.2016.02.006<\/a><\/p>\n<p><strong>Almasio, P., Bortolini, M., Pagliaro, L., &amp; Coltorti, M.<\/strong> (1990). Role of S-adenosyl-L-methionine in the treatment of intrahepatic cholestasis. <em>Drugs, 40<\/em>(Suppl. 3), 111\u2013123<\/p>\n<p><strong>Apkarian, A. V., Hashmi, J. A., &amp; Baliki, M. N.<\/strong> (2011).<br \/>\nPain and the brain: Specificity and plasticity of the brain in clinical chronic pain.<br \/>\n<em>Pain, 152<\/em>(3 Suppl), S49\u2013S64.<br \/>\nhttps:\/\/doi.org\/10.1016\/j.pain.2010.11.010<\/p>\n<p><strong>Arrieta, M.-C., et al.<\/strong> (2014).<br \/>\nThe intestinal micobiome in early life.<br \/>\n<em>Frontiers in Immunology, 5<\/em>, 427.<br \/>\n<a href=\"https:\/\/doi.org\/10.3389\/fimmu.2014.00427\">https:\/\/doi.org\/10.3389\/fimmu.2014.00427<\/a><\/p>\n<p><strong>Attwell, D., &amp; Laughlin, S. B.<\/strong> (2001).<br \/>\nAn energy budget for signaling in the grey matter of the brain.<br \/>\n<em>Journal of Cerebral Blood Flow &amp; Metabolism, 21<\/em>(10), 1133\u20131145.<br \/>\n<a href=\"https:\/\/doi.org\/10.1097\/00004647-200110000-00001\">https:\/\/doi.org\/10.1097\/00004647-200110000-00001<\/a><\/p>\n<p><strong>Azzi, A., et al.<\/strong> (2014).<br \/>\nCircadian behavior is light-reprogrammed by plastic DNA methylation.<br \/>\n<em>Nature Neuroscience, 17<\/em>(3), 377\u2013382.<br \/>\nhttps:\/\/doi.org\/10.1038\/nn.3651<\/p>\n<p><strong>B<\/strong><\/p>\n<p><strong>Bale, T. L.<\/strong> (2015).<br \/>\nEpigenetic and transgenerational reprogramming of brain development.<br \/>\n<em>Nature Neuroscience, 18<\/em>, 1359\u20131368.<br \/>\n<a href=\"https:\/\/doi.org\/10.1038\/nn.4116\">https:\/\/doi.org\/10.1038\/nn.4116<\/a><\/p>\n<p><strong>Balkwill, F. R., Capasso, M., &amp; Hagemann, T.<\/strong> (2012).<br \/>\nThe tumor microenvironment at a glance.<br \/>\n<em>Journal of Cell Science, 125<\/em>(23), 5591\u20135596.<br \/>\n<a href=\"https:\/\/doi.org\/10.1242\/jcs.116392\">https:\/\/doi.org\/10.1242\/jcs.116392<\/a><\/p>\n<p><strong>Barnes, P. J.<\/strong> (2017).<br \/>\nTargeting epigenetic regulation in chronic obstructive pulmonary disease and asthma.<br \/>\n<em>Nature Reviews Immunology, 17<\/em>(2), 81\u201396.<br \/>\n<a href=\"https:\/\/doi.org\/10.1038\/nri.2016.146\">https:\/\/doi.org\/10.1038\/nri.2016.146<\/a><\/p>\n<p><strong>Barker, D. J. P.<\/strong> (2007). The origins of the developmental origins theory. <em>Journal of Internal Medicine, 261<\/em>(5), 412\u2013417. <a href=\"https:\/\/doi.org\/10.1111\/j.1365-2796.2007.01809.x\">https:\/\/doi.org\/10.1111\/j.1365-2796.2007.01809.x<\/a><\/p>\n<p><strong>Barres, R., et al.<\/strong> (2012).<br \/>\nAcute exercise remodels promoter methylation in human skeletal muscle.<br \/>\n<em>Cell Metabolism, 15<\/em>(3), 405\u2013411.<br \/>\n<a href=\"https:\/\/doi.org\/10.1016\/j.cmet.2012.01.001\">https:\/\/doi.org\/10.1016\/j.cmet.2012.01.001<\/a><\/p>\n<p><strong>Bartolomei, M.S. &amp; Tilghman, S.M.<\/strong> (1997).<br \/>\nGenomic imprinting in mammals.<br \/>\n<em>Annual Review of Genetics<\/em>, 31, 493\u2013525.<\/p>\n<p><strong>Bartz, J. A., Zaki, J., Bolger, N., &amp; Ochsner, K. N.<\/strong> (2011).<br \/>\nSocial effects of oxytocin in humans: Context and person matter.<br \/>\n<em>Trends in Cognitive Sciences, 15<\/em>(7), 301\u2013309.<br \/>\nhttps:\/\/doi.org\/10.1016\/j.tics.2011.05.002<\/p>\n<p><strong>Bass, J., &amp; Lazar, M. A.<\/strong> (2016).<br \/>\nCircadian time signatures of fitness and disease.<br \/>\n<em>Science, 354<\/em>(6315), 994\u2013999.<br \/>\n<a href=\"https:\/\/doi.org\/10.1126\/science.aah4965\">https:\/\/doi.org\/10.1126\/science.aah4965<\/a><\/p>\n<p><strong>Baylin, S. B., &amp; Jones, P. A.<\/strong> (2016).<br \/>\nEpigenetic determinants of cancer.<br \/>\n<em>Cold Spring Harbor Perspectives in Biology, 8<\/em>(9), a019505.<br \/>\n<a href=\"https:\/\/doi.org\/10.1101\/cshperspect.a019505\">https:\/\/doi.org\/10.1101\/cshperspect.a019505<\/a><\/p>\n<p><strong>Bechtel, W., McGoohan, S., Zeisberg, E. M., et al.<\/strong> (2010).<br \/>\nMethylation determines fibroblast activation and fibrogenesis in the kidney.<br \/>\n<em>Nature Medicine, 16<\/em>, 544\u2013550.<br \/>\n<a href=\"https:\/\/doi.org\/10.1038\/nm.2135\">https:\/\/doi.org\/10.1038\/nm.2135<\/a><\/p>\n<p><strong>Berridge, M. J.<\/strong> (2012).<br \/>\nCalcium signalling remodelling and disease.<br \/>\n<em>Biochemical Society Transactions, 40<\/em>(2), 297\u2013309.<br \/>\n<a href=\"https:\/\/doi.org\/10.1042\/BST20110766\">https:\/\/doi.org\/10.1042\/BST20110766<\/a><\/p>\n<p><strong>Bird, A.<\/strong> (2002).<br \/>\nDNA methylation patterns and epigenetic memory.<br \/>\n<em>Genes &amp; Development, 16<\/em>(1), 6\u201321.<br \/>\n<a href=\"https:\/\/doi.org\/10.1101\/gad.947102\">https:\/\/doi.org\/10.1101\/gad.947102<\/a><\/p>\n<p><strong>Bird, A.<\/strong> (2007).<br \/>\nPerceptions of epigenetics.<br \/>\n<em>Nature, 447<\/em>(7143), 396\u2013398.<br \/>\n<a href=\"https:\/\/doi.org\/10.1038\/nature05913\">https:\/\/doi.org\/10.1038\/nature05913<\/a><\/p>\n<p><strong>Blackburn, E. H., Epel, E. S., &amp; Lin, J.<\/strong> (2015).<br \/>\nHuman telomere biology: A contributory and interactive factor in aging, disease risks, and protection.<br \/>\n<em>Science, 350<\/em>(6265), 1193\u20131198.<br \/>\n<a href=\"https:\/\/doi.org\/10.1126\/science.aab3389\">https:\/\/doi.org\/10.1126\/science.aab3389<\/a><\/p>\n<p><strong>Blagojevi\u0107 BD, Brunel-Muguet S, \u0160u\u0107ur R, Mladenov V, Bala\u017e I, Vollmann J, Fotopoulos V, M\u00e4der K.<\/strong> The role of spermidine in plants and humans: a pathway from climate change adaptation to health benefits. NPJ Sci Food. 2026 Feb 9;10(1):68. doi: 10.1038\/s41538-025-00695-2. PMID: 41663409; PMCID: PMC12917199.<\/p>\n<p><strong>Bowlby, J.<\/strong> (1969).<br \/>\n<em>Attachment and loss: Vol. 1. Attachment.<\/em><br \/>\nNew York, NY: Basic Books.<\/p>\n<p><strong>Boyce, W. T., &amp; Ellis, B. J.<\/strong> (2005). Biological sensitivity to context: I. An evolutionary\u2013developmental theory of the origins and functions of stress reactivity. <em>Development and Psychopathology, 17<\/em>(2), 271\u2013301. https:\/\/doi.org\/10.1017\/S0954579405050145<\/p>\n<p><strong>C<\/strong><\/p>\n<p><strong>Cacioppo, J. T., &amp; Cacioppo, S<\/strong>. (2014). Social relationships and health: The toxic effects of perceived social isolation. <em>Social and Personality Psychology Compass, 8<\/em>(2), 58\u201372. <a href=\"https:\/\/doi.org\/10.1111\/spc3.12087\">https:\/\/doi.org\/10.1111\/spc3.12087<\/a><\/p>\n<p><strong>Campisi, J.<\/strong> (2013).<br \/>\nAging, cellular senescence, and cancer.<br \/>\n<em>Annual Review of Physiology, 75<\/em>, 685\u2013705.<br \/>\n<a href=\"https:\/\/doi.org\/10.1146\/annurev-physiol-030212-183653\">https:\/\/doi.org\/10.1146\/annurev-physiol-030212-183653<\/a><\/p>\n<p><strong>Cant\u00f3, C., &amp; Auwerx, J.<\/strong> (2009).<br \/>\nCalorie restriction, SIRT1 and longevity.<br \/>\n<em>Cell Metabolism, 8<\/em>(2), 85\u201390.<br \/>\n<a href=\"https:\/\/doi.org\/10.1016\/j.cmet.2008.12.001\">https:\/\/doi.org\/10.1016\/j.cmet.2008.12.001<\/a><\/p>\n<p><strong>Carter, C. S.<\/strong> (2014).<br \/>\nOxytocin pathways and the evolution of human behavior.<br \/>\n<em>Annual Review of Psychology, 65<\/em>, 17\u201339.<br \/>\nhttps:\/\/doi.org\/10.1146\/annurev-psych-010213-115110<\/p>\n<p><strong>Caspi, A., et al.<\/strong> (2003).<br \/>\nInfluence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene.<br \/>\n<em>Science, 301<\/em>(5631), 386\u2013389.<br \/>\n<a href=\"https:\/\/doi.org\/10.1126\/science.1083968\">https:\/\/doi.org\/10.1126\/science.1083968<\/a><\/p>\n<p><strong>Cole, S. W.<\/strong> (2014).<br \/>\nHuman social genomics.<br \/>\n<em>Annual Review of Psychology, 65<\/em>, 145\u2013170.<br \/>\nhttps:\/\/doi.org\/10.1146\/annurev-psych-010213-115054<\/p>\n<p><strong>Cremer, T., &amp; Cremer, M.<\/strong> (2001).<br \/>\nChromosome territories, nuclear architecture and gene regulation.<br \/>\n<em>Nature Reviews Genetics, 2<\/em>(4), 292\u2013301.<br \/>\nhttps:\/\/doi.org\/10.1038\/35066075<\/p>\n<p><strong>Cuylen, S., Blaukopf, C., Politi, A. Z., M\u00fcller-Reichert, T., Neumann, B., Poser, I., Ellenberg, J., Hyman, A. A., &amp; Gerlich, D. W.<\/strong> (2016).<br \/>\nKi-67 acts as a biological surfactant to disperse mitotic chromosomes.<br \/>\n<em>Nature, 535<\/em>(7611), 308\u2013312.<br \/>\nhttps:\/\/doi.org\/10.1038\/nature18610<\/p>\n<p><strong>D<\/strong><\/p>\n<p><strong>Danese, A., &amp; McEwen, B. S.<\/strong> (2012).<br \/>\nAdverse childhood experiences, allostasis, and allostatic load.<br \/>\n<em>Physiology &amp; Behavior, 106<\/em>, 29\u201339.<br \/>\n<a href=\"https:\/\/doi.org\/10.1016\/j.physbeh.2011.08.019\">https:\/\/doi.org\/10.1016\/j.physbeh.2011.08.019<\/a><\/p>\n<p><strong>De Dreu, C. K. W., Greer, L. L., Van Kleef, G. A., Shalvi, S., &amp; Handgraaf, M. J. J. <\/strong><\/p>\n<p>(2010).<br \/>\nOxytocin promotes human ethnocentrism.<br \/>\n<em>Proceedings of the National Academy of Sciences, 107<\/em>(28), 1262\u20131266.<br \/>\nhttps:\/\/doi.org\/10.1073\/pnas.0909575107<\/p>\n<p><strong>De Jager, P. L., et al.<\/strong> (2014).<br \/>\nEarly alterations in DNA methylation at ANK1 in Alzheimer\u2019s disease.<br \/>\n<em>Nature Neuroscience, 17<\/em>(9), 1156\u20131163.<br \/>\n<a href=\"https:\/\/doi.org\/10.1038\/nn.3786\">https:\/\/doi.org\/10.1038\/nn.3786<\/a><\/p>\n<p><strong>Dekker, J., Marti-Renom, M. A., &amp; Mirny, L. A.<\/strong> (2013).<br \/>\nExploring the three-dimensional organization of genomes: Interpreting chromatin interaction data. <em>Nature Reviews Genetics, 14<\/em>(6), 390\u2013403.<br \/>\n<a href=\"https:\/\/doi.org\/10.1038\/nrg3454\">https:\/\/doi.org\/10.1038\/nrg3454<\/a><\/p>\n<p><strong>Dixon, J. R., Selvaraj, S., Yue, F., Kim, A., Li, Y., Shen, Y., Hu, M., Liu, J. S., &amp; Ren, B.<\/strong> (2012).<br \/>\nTopological domains in mammalian genomes identified by analysis of chromatin interactions.<br \/>\n<em>Nature, 485<\/em>(7398), 376\u2013380.<br \/>\n<a href=\"https:\/\/doi.org\/10.1038\/nature11082\">https:\/\/doi.org\/10.1038\/nature11082<\/a><\/p>\n<p><strong>Do Carmo, S., Hanzel, C., Jacobs, M., et al.<\/strong> (2016). Rescue of early BACE-1 and global DNA demethylation by S-adenosylmethionine reduces amyloid pathology and improves cognition in an Alzheimer\u2019s model. <em>Scientific Reports, 6<\/em>, 34051. <a href=\"https:\/\/doi.org\/10.1038\/srep34051\">https:\/\/doi.org\/10.1038\/srep34051<\/a><\/p>\n<p><strong>Duman, R. S., Aghajanian, G. K., Sanacora, G., &amp; Krystal, J. 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DNA methylation signatures in aging. <em>Nature Communications, 8<\/em>, 14617.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"z-0 flex min-h-&#091;46px&#093; justify-start\"><\/div>\n<\/div>\n<\/div>\n<\/section>\n<\/div>\n<\/div>\n<div class=\"pointer-events-none -mt-px h-px translate-y-&#091;calc(var(--scroll-root-safe-area-inset-bottom)-14*var(--spacing))&#093;\" aria-hidden=\"true\"><\/div>\n<\/div><\/section><\/div><\/div><\/div><\/div><!-- close content main div --><\/div><\/div><div id='after_section_3'  class='main_color av_default_container_wrap container_wrap sidebar_right'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-2388'><div class='entry-content-wrapper clearfix'>\n","protected":false},"excerpt":{"rendered":"<p>Dr Eduard Rappold, MSc is an experienced scientific researcher and a medical practitioner, who has passionately dedicated himself for decades to those suffering from dementia and geriatric patients. <\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":430,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2388","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.2 (Yoast SEO v28.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Dr. Eduard Rappold, MSc - NUGENIS<\/title>\n<meta name=\"description\" content=\"Dr Eduard Rappold, MSc is an experienced scientific researcher and a medical practitioner. 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