{"id":524,"date":"2016-11-16T12:38:14","date_gmt":"2016-11-16T11:38:14","guid":{"rendered":"https:\/\/nugenis.eu\/?page_id=524&#038;lang=en"},"modified":"2025-05-06T15:25:54","modified_gmt":"2025-05-06T13:25:54","slug":"burnout-protector","status":"publish","type":"page","link":"https:\/\/nugenis.eu\/en\/burnout-protector\/","title":{"rendered":"Epigenetic Burnout Protector"},"content":{"rendered":"\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-9i46ck-8f60cbf9a2bac0fef6e3b68023e63118\">\n.avia-section.av-9i46ck-8f60cbf9a2bac0fef6e3b68023e63118{\nbackground-repeat:no-repeat;\nbackground-image:url(https:\/\/nugenis.eu\/wp-content\/uploads\/2016\/08\/nugenis_home_10.jpg);\nbackground-position:0% 0%;\nbackground-attachment:scroll;\n}\n.avia-section.av-9i46ck-8f60cbf9a2bac0fef6e3b68023e63118 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width=\"15\" height=\"32\" viewBox=\"0 0 15 32\" preserveAspectRatio=\"xMidYMid meet\" aria-labelledby='av-svg-title-1' aria-describedby='av-svg-desc-1' role=\"graphics-symbol\" aria-hidden=\"true\">\n<title id='av-svg-title-1'>Scroll to next section<\/title>\n<desc id='av-svg-desc-1'>Scroll to next section<\/desc>\n<path d=\"M12.96 12.16q0.704-0.832 1.536 0 0.832 0.704 0 1.536l-6.272 6.144q-0.704 0.704-1.536 0l-6.272-6.144q-0.832-0.832 0-1.536 0.768-0.768 1.6 0l5.44 4.992z\"><\/path>\n<\/svg><\/a><div class='container av-section-cont-open' ><main  role=\"main\" itemprop=\"mainContentOfPage\"  class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-524'><div class='entry-content-wrapper clearfix'>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-9djxjg-baf0fcc850fda79a2b0f5ce96f1b8abe\">\n#top .av-special-heading.av-9djxjg-baf0fcc850fda79a2b0f5ce96f1b8abe{\npadding-bottom:10px;\ncolor:#ffffff;\n}\nbody .av-special-heading.av-9djxjg-baf0fcc850fda79a2b0f5ce96f1b8abe .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-9djxjg-baf0fcc850fda79a2b0f5ce96f1b8abe .special-heading-inner-border{\nborder-color:#ffffff;\n}\n.av-special-heading.av-9djxjg-baf0fcc850fda79a2b0f5ce96f1b8abe .av-subheading{\nfont-size:20px;\n}\n<\/style>\n<div  class='av-special-heading av-9djxjg-baf0fcc850fda79a2b0f5ce96f1b8abe av-special-heading-h1 custom-color-heading blockquote modern-quote modern-centered  avia-builder-el-1  el_before_av_hr  avia-builder-el-first '><h1 class='av-special-heading-tag '  itemprop=\"headline\"  >Epigenetic Burnout Protector<\/h1><div class='av_custom_color av-subheading av-subheading_below'><p>Epigenetics Protects Against Burnout and Improves Resilience<\/p>\n<\/div><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div>\n<div  class='hr av-96eg90-7a21f0a66154df6934f7692fb856205a hr-short  avia-builder-el-2  el_after_av_heading  avia-builder-el-last  hr-center'><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n\n<\/div><\/div><\/main><!-- close content main element --><\/div><\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-918slw-c474ee9a68c48317dd1f97790eddf8ea\">\n.avia-section.av-918slw-c474ee9a68c48317dd1f97790eddf8ea{\nbackground-color:#ffffff;\nbackground-image:unset;\n}\n<\/style>\n<div id='av_section_2'  class='avia-section av-918slw-c474ee9a68c48317dd1f97790eddf8ea main_color avia-section-default avia-no-border-styling  avia-builder-el-3  el_after_av_section  el_before_av_section  avia-bg-style-scroll container_wrap sidebar_right'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-524'><div class='entry-content-wrapper clearfix'>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-8haht8-2d239b85b0194d4e909d4eed6ce8f43c\">\n.flex_column.av-8haht8-2d239b85b0194d4e909d4eed6ce8f43c{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-8haht8-2d239b85b0194d4e909d4eed6ce8f43c av_one_full  avia-builder-el-4  avia-builder-el-no-sibling  first flex_column_div av-animated-generic right-to-left av-zero-column-padding  '     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-8cm0zw-94b84c6d5c1709d2d50214cdc852ef92\">\n.avia-image-container.av-8cm0zw-94b84c6d5c1709d2d50214cdc852ef92 img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-8cm0zw-94b84c6d5c1709d2d50214cdc852ef92 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-8cm0zw-94b84c6d5c1709d2d50214cdc852ef92 av-styling-no-styling avia_animated_image av-animated-when-visible-95 fade-in avia-align-center  avia-builder-el-5  el_before_av_textblock  avia-builder-el-first '   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" fetchpriority=\"high\" class='wp-image-1521 avia-img-lazy-loading-not-1521 avia_image ' src=\"https:\/\/nugenis.eu\/wp-content\/uploads\/2017\/12\/EBOP-poster-transparent-klein01-212x300.jpg\" alt='' title='EBOP poster-transparent (klein)01'  height=\"300\" width=\"212\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/nugenis.eu\/wp-content\/uploads\/2017\/12\/EBOP-poster-transparent-klein01-212x300.jpg 212w, https:\/\/nugenis.eu\/wp-content\/uploads\/2017\/12\/EBOP-poster-transparent-klein01-450x636.jpg 450w, https:\/\/nugenis.eu\/wp-content\/uploads\/2017\/12\/EBOP-poster-transparent-klein01-768x1086.jpg 768w, https:\/\/nugenis.eu\/wp-content\/uploads\/2017\/12\/EBOP-poster-transparent-klein01-729x1030.jpg 729w, https:\/\/nugenis.eu\/wp-content\/uploads\/2017\/12\/EBOP-poster-transparent-klein01-1061x1500.jpg 1061w, https:\/\/nugenis.eu\/wp-content\/uploads\/2017\/12\/EBOP-poster-transparent-klein01-499x705.jpg 499w, https:\/\/nugenis.eu\/wp-content\/uploads\/2017\/12\/EBOP-poster-transparent-klein01-scaled.jpg 1811w\" sizes=\"(max-width: 212px) 100vw, 212px\" \/><\/div><\/div><\/div><br \/>\n<section  class='av_textblock_section av-trg5w-4903a86d1b71bebf7dcf91766eea923c '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h1 style=\"text-align: center;\">EBOP\u00ae &#8211; Epigenetic Burnout Protector<\/h1>\n<h3 style=\"text-align: center;\"><br data-start=\"93\" data-end=\"96\" \/><strong data-start=\"96\" data-end=\"145\">Mental strength starts at the cellular level.<\/strong><\/h3>\n<article class=\"text-token-text-primary w-full\" dir=\"auto\" data-testid=\"conversation-turn-5\" data-scroll-anchor=\"false\">\n<div class=\"text-base my-auto mx-auto py-5 &#091;--thread-content-margin:--spacing(4)&#093; @&#091;37rem&#093;:&#091;--thread-content-margin:--spacing(6)&#093; @&#091;72rem&#093;:&#091;--thread-content-margin:--spacing(16)&#093; px-(--thread-content-margin)\">\n<div class=\"&#091;--thread-content-max-width:32rem&#093; @&#091;34rem&#093;:&#091;--thread-content-max-width:40rem&#093; @&#091;64rem&#093;:&#091;--thread-content-max-width:48rem&#093; mx-auto flex max-w-(--thread-content-max-width) flex-1 text-base gap-4 md:gap-5 lg:gap-6 group\/turn-messages focus-visible:outline-hidden\" tabindex=\"-1\">\n<div class=\"group\/conversation-turn relative flex w-full min-w-0 flex-col\">\n<div class=\"relative flex-col gap-1 md:gap-3\">\n<div class=\"flex max-w-full flex-col grow\">\n<div class=\"min-h-8 text-message relative flex w-full flex-col items-end gap-2 text-start break-words whitespace-normal &#091;.text-message+&amp;&#093;:mt-5\" dir=\"auto\" data-message-author-role=\"user\" data-message-id=\"99c0a130-18df-4da1-a2bc-c1dfc0f30d80\">\n<div class=\"flex w-full flex-col gap-1 empty:hidden items-end rtl:items-start\">\n<div class=\"relative max-w-&#091;var(--user-chat-width,70%)&#093; bg-token-message-surface rounded-3xl px-5 py-2.5\"><\/div>\n<div class=\"relative max-w-&#091;var(--user-chat-width,70%)&#093; bg-token-message-surface rounded-3xl px-5 py-2.5\">\n<div class=\"whitespace-pre-wrap\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/article>\n<article class=\"text-token-text-primary w-full\" dir=\"auto\" data-testid=\"conversation-turn-6\" data-scroll-anchor=\"false\">\n<div class=\"text-base my-auto mx-auto py-5 &#091;--thread-content-margin:--spacing(4)&#093; @&#091;37rem&#093;:&#091;--thread-content-margin:--spacing(6)&#093; @&#091;72rem&#093;:&#091;--thread-content-margin:--spacing(16)&#093; px-(--thread-content-margin)\">\n<div class=\"&#091;--thread-content-max-width:32rem&#093; @&#091;34rem&#093;:&#091;--thread-content-max-width:40rem&#093; @&#091;64rem&#093;:&#091;--thread-content-max-width:48rem&#093; mx-auto flex max-w-(--thread-content-max-width) flex-1 text-base gap-4 md:gap-5 lg:gap-6 group\/turn-messages focus-visible:outline-hidden\" tabindex=\"-1\">\n<div class=\"group\/conversation-turn relative flex w-full min-w-0 flex-col agent-turn\">\n<div class=\"relative flex-col gap-1 md:gap-3\">\n<div class=\"flex max-w-full flex-col grow\">\n<div class=\"min-h-8 text-message relative flex w-full flex-col items-end gap-2 text-start break-words whitespace-normal &#091;.text-message+&amp;&#093;:mt-5\" dir=\"auto\" data-message-author-role=\"assistant\" data-message-id=\"83417e0c-8d6f-436d-b105-783ba29713d8\" data-message-model-slug=\"gpt-4o\">\n<div class=\"flex w-full flex-col gap-1 empty:hidden first:pt-&#091;3px&#093;\">\n<div class=\"markdown prose dark:prose-invert w-full break-words light\">\n<p class=\"\" data-start=\"147\" data-end=\"385\"><strong data-start=\"147\" data-end=\"156\">EBOP\u00ae<\/strong> is your epigenetic ally during times of stress. It supports emotional balance, protects against the effects of chronic fatigue, and enhances your inner resilience \u2014 scientifically backed, highly bioavailable, and well tolerated.<\/p>\n<p class=\"\" data-start=\"387\" data-end=\"1032\">\u2714\ufe0f <strong data-start=\"390\" data-end=\"411\">Naturally active:<\/strong> Contains 100% pure (S,S)-SAMe \u2014 a naturally occurring compound in the body that declines with age and plays a key role in mood, energy, and stress resilience.<br data-start=\"570\" data-end=\"573\" \/>\u2714\ufe0f <strong data-start=\"576\" data-end=\"605\">Epigenetically optimized:<\/strong> With activated folate (Quatrefolic\u00ae), depot-form B12 (hydroxocobalamin), B6 (P5P), and zinc \u2014 ideal even for individuals with the MTHFR gene variant.<br data-start=\"755\" data-end=\"758\" \/>\u2714\ufe0f <strong data-start=\"761\" data-end=\"798\">Neuroprotective &amp; mood-enhancing:<\/strong> Supports the balance of serotonin, dopamine, and oxytocin \u2014 for greater joy, calm, and social connectedness.<br data-start=\"907\" data-end=\"910\" \/>\u2714\ufe0f <strong data-start=\"913\" data-end=\"934\" data-is-only-node=\"\">Highly tolerable:<\/strong> Free from gluten, lactose, and artificial additives \u2014 enteric-coated for optimal bioavailability.<\/p>\n<p class=\"\" data-start=\"1034\" data-end=\"1300\"><strong data-start=\"1034\" data-end=\"1055\">Who is EBOP\u00ae for?<\/strong><br data-start=\"1055\" data-end=\"1058\" \/>\u2013 For persistent mental fatigue and inner restlessness<br data-start=\"1112\" data-end=\"1115\" \/>\u2013 For those at risk of burnout or experiencing social withdrawal<br data-start=\"1179\" data-end=\"1182\" \/>\u2013 As supportive care for low mood or emotional exhaustion<br data-start=\"1239\" data-end=\"1242\" \/>\u2013 To promote mood, sleep quality, and emotional resilience<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/article>\n<h3 data-start=\"156\" data-end=\"187\"><\/h3>\n<h3 class=\"\" data-start=\"156\" data-end=\"187\"><strong data-start=\"160\" data-end=\"185\">Dosage Recommendation<\/strong><\/h3>\n<p class=\"\" data-start=\"188\" data-end=\"402\">Take 1\u20132 capsules daily with plenty of water, preferably in the morning on an empty stomach or between meals.<br data-start=\"297\" data-end=\"300\" \/>Dosage can be adjusted based on individual needs and upon recommendation by a healthcare professional.<\/p>\n<hr class=\"\" data-start=\"404\" data-end=\"407\" \/>\n<h3 class=\"\" data-start=\"409\" data-end=\"440\"><strong data-start=\"413\" data-end=\"438\">Possible Side Effects<\/strong><\/h3>\n<p class=\"\" data-start=\"441\" data-end=\"541\">EBOP\u00ae is generally well tolerated at the recommended dosage. In rare cases, the following may occur:<\/p>\n<ul data-start=\"543\" data-end=\"690\">\n<li class=\"\" data-start=\"543\" data-end=\"690\">\n<p class=\"\" data-start=\"545\" data-end=\"690\">Gastrointestinal discomfort (nausea, bloating, or soft stools)<br data-start=\"607\" data-end=\"610\" \/>These effects are usually dose-dependent and subside when the dosage is reduced.<\/p>\n<\/li>\n<\/ul>\n<hr class=\"\" data-start=\"692\" data-end=\"695\" \/>\n<h3 class=\"\" data-start=\"697\" data-end=\"727\"><strong data-start=\"701\" data-end=\"727\">Potential Interactions<\/strong><\/h3>\n<ul data-start=\"729\" data-end=\"1201\">\n<li class=\"\" data-start=\"729\" data-end=\"908\">\n<p class=\"\" data-start=\"731\" data-end=\"908\"><strong data-start=\"731\" data-end=\"804\">SSRIs, MAO inhibitors, tricyclic antidepressants, serotonin agonists:<\/strong><br data-start=\"804\" data-end=\"807\" \/>May increase serotonin levels further; consult your doctor to avoid the risk of serotonin syndrome.<\/p>\n<\/li>\n<li class=\"\" data-start=\"910\" data-end=\"1032\">\n<p class=\"\" data-start=\"912\" data-end=\"1032\"><strong data-start=\"912\" data-end=\"929\">Methotrexate:<\/strong><br data-start=\"929\" data-end=\"932\" \/>May interfere with folate metabolism \u2014 maintaining adequate folate status is especially important.<\/p>\n<\/li>\n<li class=\"\" data-start=\"1034\" data-end=\"1201\">\n<p class=\"\" data-start=\"1036\" data-end=\"1201\"><strong data-start=\"1036\" data-end=\"1057\">Zinc supplements:<\/strong><br data-start=\"1057\" data-end=\"1060\" \/>Zinc absorption may be reduced if taken together with high-iron or high-calcium products.<br data-start=\"1151\" data-end=\"1154\" \/>\u2192 A time gap of about 2 hours is recommended.<\/p>\n<\/li>\n<\/ul>\n<hr class=\"\" data-start=\"1203\" data-end=\"1206\" \/>\n<h3 class=\"\" data-start=\"1208\" data-end=\"1233\"><strong data-start=\"1212\" data-end=\"1233\">Contraindications<\/strong><\/h3>\n<p class=\"\" data-start=\"1235\" data-end=\"1282\">Do not use EBOP\u00ae if any of the following apply:<\/p>\n<ul data-start=\"1284\" data-end=\"1601\">\n<li class=\"\" data-start=\"1284\" data-end=\"1336\">\n<p class=\"\" data-start=\"1286\" data-end=\"1336\">Known hypersensitivity to any of the ingredients<\/p>\n<\/li>\n<li class=\"\" data-start=\"1337\" data-end=\"1393\">\n<p class=\"\" data-start=\"1339\" data-end=\"1393\">Use in children or adolescents under 18 years of age<\/p>\n<\/li>\n<li class=\"\" data-start=\"1394\" data-end=\"1480\">\n<p class=\"\" data-start=\"1396\" data-end=\"1480\">During pregnancy or breastfeeding (unless specifically recommended by a physician)<\/p>\n<\/li>\n<li class=\"\" data-start=\"1481\" data-end=\"1601\">\n<p class=\"\" data-start=\"1483\" data-end=\"1601\">In cases of existing psychiatric conditions or when taking psychiatric medication \u2014 use only under medical supervision<\/p>\n<\/li>\n<\/ul>\n<hr class=\"\" data-start=\"1603\" data-end=\"1606\" \/>\n<p class=\"\" data-start=\"1608\" data-end=\"1792\"><strong data-start=\"1608\" data-end=\"1617\">Note:<\/strong><br data-start=\"1617\" data-end=\"1620\" \/>Dietary supplements are not a substitute for a balanced diet and a healthy lifestyle. If you have any health concerns or medical conditions, consult your doctor before<\/p>\n<article class=\"text-token-text-primary w-full\" dir=\"auto\" data-testid=\"conversation-turn-6\" data-scroll-anchor=\"false\">\n<div class=\"text-base my-auto mx-auto py-5 &#091;--thread-content-margin:--spacing(4)&#093; @&#091;37rem&#093;:&#091;--thread-content-margin:--spacing(6)&#093; @&#091;72rem&#093;:&#091;--thread-content-margin:--spacing(16)&#093; px-(--thread-content-margin)\">\n<div class=\"&#091;--thread-content-max-width:32rem&#093; @&#091;34rem&#093;:&#091;--thread-content-max-width:40rem&#093; @&#091;64rem&#093;:&#091;--thread-content-max-width:48rem&#093; mx-auto flex max-w-(--thread-content-max-width) flex-1 text-base gap-4 md:gap-5 lg:gap-6 group\/turn-messages focus-visible:outline-hidden\" tabindex=\"-1\">\n<div class=\"group\/conversation-turn relative flex w-full min-w-0 flex-col agent-turn\">\n<div class=\"relative flex-col gap-1 md:gap-3\">\n<div class=\"flex max-w-full flex-col grow\">\n<div class=\"min-h-8 text-message relative flex w-full flex-col items-end gap-2 text-start break-words whitespace-normal &#091;.text-message+&amp;&#093;:mt-5\" dir=\"auto\" data-message-author-role=\"assistant\" data-message-id=\"83417e0c-8d6f-436d-b105-783ba29713d8\" data-message-model-slug=\"gpt-4o\">\n<div class=\"flex w-full flex-col gap-1 empty:hidden first:pt-&#091;3px&#093;\">\n<div class=\"markdown prose dark:prose-invert w-full break-words light\">\n<h3 style=\"text-align: center;\" data-start=\"1302\" data-end=\"1400\"><strong data-start=\"1302\" data-end=\"1342\">EBOP\u00ae \u2013 Mental strength from within.<\/strong><br data-start=\"1342\" data-end=\"1345\" \/>Natural. Highly bioavailable. Epigenetically effective.<\/h3>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/article>\n<h3 data-start=\"156\" data-end=\"187\"><\/h3>\n<p>More about this:<\/p>\n<p>&#8216;Burnout is defined by the World Health Organization (WHO) as a syndrome resulting from &#8216;chronic workplace stress that has not been successfully managed.&#8217;<\/p>\n<p>Symptoms of Burnout:<\/p>\n<ul>\n<li>Physical and mental exhaustion<\/li>\n<li>Negative self-assessment of one&#8217;s own resilience and professional competence<\/li>\n<li>Negative feelings towards work<\/li>\n<li>Loss of compassionate attitude towards clients<\/li>\n<\/ul>\n<p>\u25ca Cochrane&#8217;s evaluation of Ademetionine compared to other antidepressants: Risk ratios and effect size calculations for S-Adenosylmethionine (SAM, Ademetionin, AdoMet) compared to other antidepressants show no statistically significant difference. These results suggest that both therapies are approximately equal in their effects. AHRQ Evidence Report Summaries, Rockville.<\/p>\n<p>Epigenetic Connections with Serotonin:<\/p>\n<ul>\n<li>A gene variant of the serotonin transporter gene (Variant &#8216;K&#8217;) leads to dysfunction of the serotonergic synapse with functional serotonin deficiency despite normal plasma serotonin levels.<\/li>\n<li>Serotonin, known colloquially as the &#8216;happiness hormone,&#8217; serves important physiological functions in the digestive tract, bloodstream, and central nervous system.<\/li>\n<li>Serotonin acts as a neurotransmitter in the brain, transmitting signals between nerve cells. It is the phylogenetically oldest and universally acting neurotransmitter in all parts of the brain.<\/li>\n<li>A polymorphism in the promoter region of the serotonin transporter gene SLC6A4 has a shortened gene variant (Variant &#8216;K&#8217;) and is associated with anxiety disorders, obsessive-compulsive disorders, toxic stress, depressive disorders, and burnout. The shortened gene variant of the serotonin transporter is also found in fibromyalgia and lowered pain threshold.<\/li>\n<\/ul>\n<p>Disease symptoms with serotonin deficiency:<\/p>\n<ul>\n<li>Suspected functional serotonin deficiency with normal serotonin levels is indicated by chronic fatigue symptoms, lack of motivation, mood narrowing, loss of affective resonance, anxiety, and sleep disorders.<\/li>\n<li>Mood narrowing, loss of affective resonance, anxiety, reduced drive, and sleep disorders are the key symptoms in diseases related to the depressive spectrum.<\/li>\n<\/ul>\n<p>Metabolic diversity of serotonin:<\/p>\n<ul>\n<li>Serotonin is synthesized into melatonin with its sleep-inducing effect.<\/li>\n<li>Adequate serotonin in the brain leads to an increase in oxytocin and aids in social recognition. Social recognition is regulated by a network of oxytocin-sensitive neurons in the hippocampus.<\/li>\n<li>Increased activity of the neuronal stress axis as a result of toxic stress.<\/li>\n<\/ul>\n<p>Neuronal stress response is adaptable and beneficial in the short term but, when excessively activated, can lead to altered physical responses to stress (toxic stress). Constant subjective stress is associated with elevated levels of norepinephrine, adrenaline, and cortisol. There is a lack of a relaxation phase, elevated heart rate and blood pressure, weakened immune competence, and toxic stress negatively impacts the life expectancy of affected individuals.<\/p>\n<p>Oxidative stress is the main cause of cell aging:<\/p>\n<ul>\n<li>Stress increases serotonin levels in healthy individuals, as well as norepinephrine, dopamine, and cortisol levels.<\/li>\n<li>Cortisol elevation in toxic stress, mediated by the activation of the adrenergic system and \u03b11-adrenergic receptors, leads to the release of the stress hormone CRH (Corticotropin-Releasing-Hormone), activating the subsequent stages of the HPA axis. The cortisol, being fat-soluble, easily passes the blood-brain barrier and influences the expression of numerous genes by acting as a transcription factor.<\/li>\n<li>The hippocampus, a region of the brain with dense serotonergic innervation, is crucial for stress regulation.<\/li>\n<\/ul>\n<p>Toxic stress results in a decrease in neurogenesis in the dentate gyrus of the hippocampus, leading to reduced proliferation, survival rate, and differentiation of neural stem cells. Under toxic stress and in response to constantly elevated cortisol, the dentate gyrus experiences a decrease in cell count through the inhibition of neurogenesis, while physical activity and an enriched environment increase the volume of the dentate gyrus and the number of neurons.<\/p>\n<p>Toxic stress also leads to hypomethylation of the glucocorticoid receptor gene locus, resulting in increased MaoB expression. MaoA and MaoB activity is increased by cortisol. The toxic byproducts formed during oxidative deamination, known as reactive oxygen species (ROS), include hyperoxide anion (O2\u00b7-), hydroxyl radical (HO\u00b7), peroxyl radical (ROO\u00b7), alkoxyl radical (RO\u00b7), and hydrogen peroxide (H2O2). These lead to mitochondrial dysfunction and subsequent neurotoxicity, resulting in neurodegeneration and astrogliosis in brain cells.<\/p>\n<p>About 75% of MAO in the human brain belongs to the B-subtype (Saura Marti et al., 1990).<\/p>\n<p>Toxic stress and its role in the development of Alzheimer&#8217;s disease: Toxic stress with an overactive stress axis, described as the HPA axis (hypothalamic\u2013pituitary\u2013adrenal axis), also plays a significant role in the development of Alzheimer&#8217;s disease.<\/p>\n<p>\u25ca Is dementia and depression a malfunction of neurogenesis and neuroprotection? Current concepts of depression and cerebral aging have shifted from dysfunction of neurotransmission to dysfunction of neurogenesis and neuroprotection (Bettina H. Bewernick 2013).<\/p>\n<p>Neurons are unique cells that persist throughout an individual&#8217;s entire lifespan, undergoing programmed developmental changes and accumulating environmental experiences that optimize neural circuits in the brain. Neurons undergo precisely coordinated cascades of genetic regulation during development and maturation, connecting with experience to shape cellular production through progressive changes in the epigenome.<\/p>\n<p>Neurogenesis (formation of new neurons): It has been shown that neurogenesis can be inhibited by physical and social stress, depression, and treatment with antidepressants. Berton O., Nestler EJ. New approaches to discovering antidepressants: beyond monoamines. Nat Rev Neurosci. 2006; 7: 137\u2013151.<\/p>\n<p>EBOP\u00ae &#8211; Epigenetic Burnout Protector consists of naturally occurring substances in the body:<\/p>\n<ul>\n<li>Ademetionine (S-Adenosylmethionine): The production of S-Adenosylmethionine (Ademetionine) in humans mainly occurs in the liver. A liver-healthy adult under 30 years old synthesizes approximately eight grams of S-Adenosylmethionine (SAM, Ademetionin) per day. The natural occurrence of Ademetionine in the cell and its biosynthesis in liver cells decrease with age after 35. This age-dependent Ademetionine deficiency leads to hypomethylation (undermethylation) of DNA, resulting in epigenetically caused diseases. For your benefit, we use: ADOGRAN\u00ae &#8211; a coated (acid- and water-resistant) granule of Ademetionine, and an acid-resistant capsule shell protects the integrity of the active form of S-Adenosylmethionine (SAM, Ademetionin).<\/li>\n<li>Vitamin B12: Supports the metabolic functions of our brain cells, maintaining the normal function of the nervous system and normal psychological functions (according to Regulation (EU) No 432\/2012). Vitamin B12 supports Ademetionine production. For your benefit, we use: Hydroxocobalamin &#8211; Vitamin B12 in our product. Among all forms of Vitamin B12, Hydroxocobalamin has the best depot effect in brain cells. It binds particularly well to the body&#8217;s transport molecules, circulating in the blood for an extended period and spontaneously converting into one of the bioactive forms, Methylcobalamin or Adenosylcobalamin, in the organs (nerves, muscles, brain).<\/li>\n<li>Folic Acid: Contributes to normal amino acid synthesis and supports the dispositional provision of the essential amino acid methionine in the one-carbon cycle. Folic acid contributes to normal homocysteine metabolism, avoiding the risk factor of hyperhomocysteinemia. Folic acid contributes to normal psychological function, providing methionine and ensuring sufficient Ademetionine synthesis. Folic Acid contributes to the normal function of the immune system (according to Regulation (EU) No 432\/2012). For your benefit, we use: QUATREFOLIC\u00ae &#8211; the glucosamine salt of 5-Methyltetrahydrofolate. Quatrefolic\u00ae is the so-called fourth generation of folates. Its high bioavailability avoids hyperhomocysteinemia. The Methyltetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-Methyltetrahydrofolate, a methyl group donor for methionine synthesis. L-Methionine is a precursor of Ademetionine. The most common mutation variant in the Folic Acid is a point mutation at position 677. Homozygous (two identical alleles) carriers of the genetic trait, found in 5 to 20% of the population, experience a 50% loss of activity. This polymorphism in the MTHFR gene type 677T often leads to a mild to moderate increase in plasma homocysteine concentration, especially with low B12 or Folic Acid status. Hyperhomocysteinemia is an established risk factor for cardiovascular diseases, non-alcoholic fatty liver, and is proven to cause Alzheimer&#8217;s pathology.<\/li>\n<li>Vitamin B6: Contributes to normal psychological function. Vitamin B6 contributes to normal homocysteine metabolism and helps reduce tiredness and fatigue (according to Regulation (EU) No 432\/2012). For your benefit, we use: VITAMIN B6 in our product in its activated form as PYRIDOXAL-5-PHOSPHATE (P5P), which breaks down Homocysteine.<\/li>\n<\/ul>\n<p>Together, Ademetionine, Hydroxocobalamin, Quatrefolic\u00ae, and Pyridoxal-5-Phosphate prevent an increase in blood Homocysteine levels, making a significant contribution to the safety of physical and mental health.<\/p>\n<ul>\n<li>Zinc: Contributes to protecting cells from oxidative stress (according to EU Regulation No 432\/2012). Oxidative stress is the main cause of cell aging.<\/li>\n<\/ul>\n<p>The use of EBOP\u00ae &#8211; Epigenetic Burnout Protector aims to provide a comprehensive protective shield for brain cells through these essential components, ensuring optimal cognitive function and promoting overall well-being.<\/p>\n<p>Note: This information is provided for educational purposes and does not substitute for professional medical advice. Always consult with healthcare providers for personalized guidance on health-related matters.<\/p>\n<p><strong>Copyright<\/strong> \u00a9 Eduard Rappold 2025<\/p>\n<\/div><\/section><\/p><\/div><\/div><\/div><\/div><!-- close content main div --><\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-3tvcyk-1de082ce0df804dcd65f9c40f0fbdee2\">\n.avia-section.av-3tvcyk-1de082ce0df804dcd65f9c40f0fbdee2{\nbackground-color:#fafafa;\nbackground-image:unset;\n}\n<\/style>\n<div id='av_section_3'  class='avia-section av-3tvcyk-1de082ce0df804dcd65f9c40f0fbdee2 main_color avia-section-default avia-no-border-styling  avia-builder-el-7  el_after_av_section  el_before_av_section  avia-bg-style-scroll container_wrap sidebar_right'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-524'><div class='entry-content-wrapper clearfix'>\n\n<style 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src=\"https:\/\/nugenis.eu\/wp-content\/uploads\/2020\/10\/ebp-vo2-450x450.jpg\" class=\"wp-image-4600 avia-img-lazy-loading-4600 attachment-shop_catalog size-shop_catalog wp-post-image\" alt=\"\" srcset=\"https:\/\/nugenis.eu\/wp-content\/uploads\/2020\/10\/ebp-vo2-450x450.jpg 450w, https:\/\/nugenis.eu\/wp-content\/uploads\/2020\/10\/ebp-vo2-100x100.jpg 100w, https:\/\/nugenis.eu\/wp-content\/uploads\/2020\/10\/ebp-vo2-300x300.jpg 300w, https:\/\/nugenis.eu\/wp-content\/uploads\/2020\/10\/ebp-vo2-80x80.jpg 80w, https:\/\/nugenis.eu\/wp-content\/uploads\/2020\/10\/ebp-vo2-768x768.jpg 768w, https:\/\/nugenis.eu\/wp-content\/uploads\/2020\/10\/ebp-vo2-36x36.jpg 36w, https:\/\/nugenis.eu\/wp-content\/uploads\/2020\/10\/ebp-vo2-180x180.jpg 180w, https:\/\/nugenis.eu\/wp-content\/uploads\/2020\/10\/ebp-vo2-705x705.jpg 705w, https:\/\/nugenis.eu\/wp-content\/uploads\/2020\/10\/ebp-vo2.jpg 1000w\" sizes=\"auto, (max-width: 450px) 100vw, 450px\" \/><span class=\"cart-loading\"><\/span><\/div><div class='inner_product_header'><div class='avia-arrow'><\/div><div class='inner_product_header_table'><div class='inner_product_header_cell'><h2 class=\"woocommerce-loop-product__title\">EBP\u00ae<br>Epigenetic Brain Protector<\/h2>\n\t<span class=\"price\"><span class=\"woocommerce-Price-amount amount\"><bdi>49,90&nbsp;<span class=\"woocommerce-Price-currencySymbol\" translate=\"no\">&euro;<\/span><\/bdi><\/span> <small class=\"woocommerce-price-suffix\">inkl. MwSt.<\/small><\/span>\n\n\n\n<\/div><\/div><\/div><\/a>\n\n\t<p class=\"wc-gzd-additional-info wc-gzd-additional-info-loop shipping-costs-info\">zzgl. <a href=\"https:\/\/nugenis.eu\/versandarten\/\" target=\"_blank\">Versandkosten<\/a><\/p>\n\n\n\t<p class=\"wc-gzd-additional-info wc-gzd-additional-info-loop product-units-wrapper product-units\">Produkt enth\u00e4lt: 0,83 <span class=\"unit\">Kapsel<\/span><\/p>\n<div class='avia_cart_buttons '><a href=\"\/en\/wp-json\/wp\/v2\/pages\/524?add-to-cart=3344\" aria-describedby=\"woocommerce_loop_add_to_cart_link_describedby_3344\" data-quantity=\"1\" class=\"button product_type_simple add_to_cart_button ajax_add_to_cart\" data-product_id=\"3344\" data-product_sku=\"10\" aria-label=\"Add to cart: &ldquo;EBP\u00aeEpigenetic Brain Protector&rdquo;\" rel=\"nofollow\" data-success_message=\"&ldquo;EBP\u00ae&lt;br&gt;Epigenetic Brain Protector&rdquo; has been added to your cart\" role=\"button\"><span class=\"avia-svg-icon avia-font-svg_entypo-fontello\" data-av_svg_icon='basket' data-av_iconset='svg_entypo-fontello'><svg version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"29\" height=\"32\" viewBox=\"0 0 29 32\" preserveAspectRatio=\"xMidYMid meet\" aria-labelledby='av-svg-title-2' aria-describedby='av-svg-desc-2' role=\"graphics-symbol\" aria-hidden=\"true\">\n<title id='av-svg-title-2'>Add to cart<\/title>\n<desc id='av-svg-desc-2'>Add to cart<\/desc>\n<path d=\"M4.8 27.2q0-1.28 0.96-2.24t2.24-0.96q1.344 0 2.272 0.96t0.928 2.24q0 1.344-0.928 2.272t-2.272 0.928q-1.28 0-2.24-0.928t-0.96-2.272zM20.8 27.2q0-1.28 0.96-2.24t2.24-0.96q1.344 0 2.272 0.96t0.928 2.24q0 1.344-0.928 2.272t-2.272 0.928q-1.28 0-2.24-0.928t-0.96-2.272zM10.496 19.648q-1.152 0.32-1.088 0.736t1.408 0.416h17.984v2.432q0 0.64-0.64 0.64h-20.928q-0.64 0-0.64-0.64v-2.432l-0.32-1.472-3.136-14.528h-3.136v-2.56q0-0.64 0.64-0.64h4.992q0.64 0 0.64 0.64v2.752h22.528v8.768q0 0.704-0.576 0.832z\"><\/path>\n<\/svg><\/span>  Add to cart<\/a>\t<span id=\"woocommerce_loop_add_to_cart_link_describedby_3344\" class=\"screen-reader-text\">\n\t\t\t<\/span>\n<a class=\"button show_details_button\" href=\"https:\/\/nugenis.eu\/en\/produkt\/ebp-epigenetic-brain-protector\/\"><span class=\"avia-svg-icon avia-font-svg_entypo-fontello\" data-av_svg_icon='doc-text' data-av_iconset='svg_entypo-fontello'><svg version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"22\" height=\"32\" viewBox=\"0 0 22 32\" preserveAspectRatio=\"xMidYMid meet\" aria-labelledby='av-svg-title-3' aria-describedby='av-svg-desc-3' role=\"graphics-symbol\" aria-hidden=\"true\">\n<title id='av-svg-title-3'>Show Details<\/title>\n<desc id='av-svg-desc-3'>Show Details<\/desc>\n<path d=\"M6.784 17.344v-2.88h8.96v2.88h-8.96zM19.2 1.6q1.344 0 2.272 0.928t0.928 2.272v22.4q0 1.28-0.928 2.24t-2.272 0.96h-16q-1.28 0-2.24-0.96t-0.96-2.24v-22.4q0-1.344 0.96-2.272t2.24-0.928h16zM19.2 27.2v-22.4h-16v22.4h16zM15.68 8.256v2.816h-8.96v-2.816h8.96zM15.68 20.8v2.816h-8.96v-2.816h8.96z\"><\/path>\n<\/svg><\/span>  Show Details<\/a> <span class=\"button-mini-delimiter\"><\/span><\/div><\/div><\/li>\n<li class=\"product type-product post-3356 status-publish instock has-post-thumbnail taxable shipping-taxable purchasable product-type-simple\">\n\t<div class='inner_product main_color wrapped_style noLightbox  av-product-class-'><a href=\"https:\/\/nugenis.eu\/en\/produkt\/ebop-epigenetic-burnout-protector\/\" class=\"woocommerce-LoopProduct-link woocommerce-loop-product__link\"><div class=\"thumbnail_container\"><img decoding=\"async\" loading=\"lazy\" width=\"450\" height=\"450\" src=\"https:\/\/nugenis.eu\/wp-content\/uploads\/2020\/10\/ebop-v02-450x450.jpg\" class=\"wp-image-4597 avia-img-lazy-loading-4597 attachment-shop_catalog size-shop_catalog wp-post-image\" alt=\"\" srcset=\"https:\/\/nugenis.eu\/wp-content\/uploads\/2020\/10\/ebop-v02-450x450.jpg 450w, https:\/\/nugenis.eu\/wp-content\/uploads\/2020\/10\/ebop-v02-100x100.jpg 100w, https:\/\/nugenis.eu\/wp-content\/uploads\/2020\/10\/ebop-v02-300x300.jpg 300w, https:\/\/nugenis.eu\/wp-content\/uploads\/2020\/10\/ebop-v02-80x80.jpg 80w, https:\/\/nugenis.eu\/wp-content\/uploads\/2020\/10\/ebop-v02-768x768.jpg 768w, https:\/\/nugenis.eu\/wp-content\/uploads\/2020\/10\/ebop-v02-36x36.jpg 36w, https:\/\/nugenis.eu\/wp-content\/uploads\/2020\/10\/ebop-v02-180x180.jpg 180w, https:\/\/nugenis.eu\/wp-content\/uploads\/2020\/10\/ebop-v02-705x705.jpg 705w, https:\/\/nugenis.eu\/wp-content\/uploads\/2020\/10\/ebop-v02.jpg 1000w\" sizes=\"auto, (max-width: 450px) 100vw, 450px\" \/><span class=\"cart-loading\"><\/span><\/div><div class='inner_product_header'><div class='avia-arrow'><\/div><div class='inner_product_header_table'><div class='inner_product_header_cell'><h2 class=\"woocommerce-loop-product__title\">EBOP\u00ae<br>Epigenetic Burnout Protector<\/h2>\n\t<span class=\"price\"><span class=\"woocommerce-Price-amount amount\"><bdi>49,90&nbsp;<span class=\"woocommerce-Price-currencySymbol\" translate=\"no\">&euro;<\/span><\/bdi><\/span> <small class=\"woocommerce-price-suffix\">inkl. MwSt.<\/small><\/span>\n\n\n\n<\/div><\/div><\/div><\/a>\n\n\t<p class=\"wc-gzd-additional-info wc-gzd-additional-info-loop shipping-costs-info\">zzgl. <a href=\"https:\/\/nugenis.eu\/versandarten\/\" target=\"_blank\">Versandkosten<\/a><\/p>\n\n\n<div class='avia_cart_buttons '><a href=\"\/en\/wp-json\/wp\/v2\/pages\/524?add-to-cart=3356\" aria-describedby=\"woocommerce_loop_add_to_cart_link_describedby_3356\" data-quantity=\"1\" class=\"button product_type_simple add_to_cart_button ajax_add_to_cart\" data-product_id=\"3356\" data-product_sku=\"20\" aria-label=\"Add to cart: &ldquo;EBOP\u00aeEpigenetic Burnout Protector&rdquo;\" rel=\"nofollow\" data-success_message=\"&ldquo;EBOP\u00ae&lt;br&gt;Epigenetic Burnout Protector&rdquo; has been added to your cart\" role=\"button\"><span class=\"avia-svg-icon avia-font-svg_entypo-fontello\" data-av_svg_icon='basket' data-av_iconset='svg_entypo-fontello'><svg version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"29\" height=\"32\" viewBox=\"0 0 29 32\" preserveAspectRatio=\"xMidYMid meet\" aria-labelledby='av-svg-title-4' aria-describedby='av-svg-desc-4' role=\"graphics-symbol\" aria-hidden=\"true\">\n<title id='av-svg-title-4'>Add to cart<\/title>\n<desc id='av-svg-desc-4'>Add to cart<\/desc>\n<path d=\"M4.8 27.2q0-1.28 0.96-2.24t2.24-0.96q1.344 0 2.272 0.96t0.928 2.24q0 1.344-0.928 2.272t-2.272 0.928q-1.28 0-2.24-0.928t-0.96-2.272zM20.8 27.2q0-1.28 0.96-2.24t2.24-0.96q1.344 0 2.272 0.96t0.928 2.24q0 1.344-0.928 2.272t-2.272 0.928q-1.28 0-2.24-0.928t-0.96-2.272zM10.496 19.648q-1.152 0.32-1.088 0.736t1.408 0.416h17.984v2.432q0 0.64-0.64 0.64h-20.928q-0.64 0-0.64-0.64v-2.432l-0.32-1.472-3.136-14.528h-3.136v-2.56q0-0.64 0.64-0.64h4.992q0.64 0 0.64 0.64v2.752h22.528v8.768q0 0.704-0.576 0.832z\"><\/path>\n<\/svg><\/span>  Add to cart<\/a>\t<span id=\"woocommerce_loop_add_to_cart_link_describedby_3356\" class=\"screen-reader-text\">\n\t\t\t<\/span>\n<a class=\"button show_details_button\" href=\"https:\/\/nugenis.eu\/en\/produkt\/ebop-epigenetic-burnout-protector\/\"><span class=\"avia-svg-icon avia-font-svg_entypo-fontello\" data-av_svg_icon='doc-text' data-av_iconset='svg_entypo-fontello'><svg version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"22\" height=\"32\" viewBox=\"0 0 22 32\" preserveAspectRatio=\"xMidYMid meet\" aria-labelledby='av-svg-title-5' aria-describedby='av-svg-desc-5' role=\"graphics-symbol\" aria-hidden=\"true\">\n<title id='av-svg-title-5'>Show Details<\/title>\n<desc id='av-svg-desc-5'>Show Details<\/desc>\n<path d=\"M6.784 17.344v-2.88h8.96v2.88h-8.96zM19.2 1.6q1.344 0 2.272 0.928t0.928 2.272v22.4q0 1.28-0.928 2.24t-2.272 0.96h-16q-1.28 0-2.24-0.96t-0.96-2.24v-22.4q0-1.344 0.96-2.272t2.24-0.928h16zM19.2 27.2v-22.4h-16v22.4h16zM15.68 8.256v2.816h-8.96v-2.816h8.96zM15.68 20.8v2.816h-8.96v-2.816h8.96z\"><\/path>\n<\/svg><\/span>  Show Details<\/a> <span class=\"button-mini-delimiter\"><\/span><\/div><\/div><\/li>\n<li class=\"product type-product post-7201 status-publish last instock has-post-thumbnail taxable shipping-taxable purchasable product-type-simple\">\n\t<div class='inner_product main_color wrapped_style noLightbox  av-product-class-'><a href=\"https:\/\/nugenis.eu\/en\/produkt\/sam-e\/\" class=\"woocommerce-LoopProduct-link woocommerce-loop-product__link\"><div class=\"thumbnail_container\"><img decoding=\"async\" loading=\"lazy\" width=\"450\" height=\"450\" src=\"https:\/\/nugenis.eu\/wp-content\/uploads\/2024\/04\/mockup-sam-e-transparent-4000x4000-weiss-450x450.png\" class=\"wp-image-7715 avia-img-lazy-loading-7715 attachment-shop_catalog size-shop_catalog wp-post-image\" alt=\"Produktbild Sam-E\" srcset=\"https:\/\/nugenis.eu\/wp-content\/uploads\/2024\/04\/mockup-sam-e-transparent-4000x4000-weiss-450x450.png 450w, https:\/\/nugenis.eu\/wp-content\/uploads\/2024\/04\/mockup-sam-e-transparent-4000x4000-weiss-300x300.png 300w, https:\/\/nugenis.eu\/wp-content\/uploads\/2024\/04\/mockup-sam-e-transparent-4000x4000-weiss-1030x1030.png 1030w, https:\/\/nugenis.eu\/wp-content\/uploads\/2024\/04\/mockup-sam-e-transparent-4000x4000-weiss-80x80.png 80w, https:\/\/nugenis.eu\/wp-content\/uploads\/2024\/04\/mockup-sam-e-transparent-4000x4000-weiss-768x768.png 768w, https:\/\/nugenis.eu\/wp-content\/uploads\/2024\/04\/mockup-sam-e-transparent-4000x4000-weiss-1536x1536.png 1536w, https:\/\/nugenis.eu\/wp-content\/uploads\/2024\/04\/mockup-sam-e-transparent-4000x4000-weiss-2048x2048.png 2048w, https:\/\/nugenis.eu\/wp-content\/uploads\/2024\/04\/mockup-sam-e-transparent-4000x4000-weiss-36x36.png 36w, https:\/\/nugenis.eu\/wp-content\/uploads\/2024\/04\/mockup-sam-e-transparent-4000x4000-weiss-180x180.png 180w, https:\/\/nugenis.eu\/wp-content\/uploads\/2024\/04\/mockup-sam-e-transparent-4000x4000-weiss-1500x1500.png 1500w, https:\/\/nugenis.eu\/wp-content\/uploads\/2024\/04\/mockup-sam-e-transparent-4000x4000-weiss-705x705.png 705w, https:\/\/nugenis.eu\/wp-content\/uploads\/2024\/04\/mockup-sam-e-transparent-4000x4000-weiss-120x120.png 120w, https:\/\/nugenis.eu\/wp-content\/uploads\/2024\/04\/mockup-sam-e-transparent-4000x4000-weiss-100x100.png 100w\" sizes=\"auto, (max-width: 450px) 100vw, 450px\" \/><span class=\"cart-loading\"><\/span><\/div><div class='inner_product_header'><div class='avia-arrow'><\/div><div class='inner_product_header_table'><div class='inner_product_header_cell'><h2 class=\"woocommerce-loop-product__title\">SAM-e 100% active 400mg\/Capsule &#8211; 30 Capsules<\/h2>\n\t<span class=\"price\"><span class=\"woocommerce-Price-amount amount\"><bdi>49,90&nbsp;<span class=\"woocommerce-Price-currencySymbol\" translate=\"no\">&euro;<\/span><\/bdi><\/span> <small class=\"woocommerce-price-suffix\">inkl. MwSt.<\/small><\/span>\n\n\n\n<\/div><\/div><\/div><\/a>\n\n\t<p class=\"wc-gzd-additional-info wc-gzd-additional-info-loop shipping-costs-info\">zzgl. <a href=\"https:\/\/nugenis.eu\/versandarten\/\" target=\"_blank\">Versandkosten<\/a><\/p>\n\n\n<div class='avia_cart_buttons '><a href=\"\/en\/wp-json\/wp\/v2\/pages\/524?add-to-cart=7201\" aria-describedby=\"woocommerce_loop_add_to_cart_link_describedby_7201\" data-quantity=\"1\" class=\"button product_type_simple add_to_cart_button ajax_add_to_cart\" data-product_id=\"7201\" data-product_sku=\"60\" aria-label=\"Add to cart: &ldquo;SAM-e 100% active 400mg\/Capsule - 30 Capsules&rdquo;\" rel=\"nofollow\" data-success_message=\"&ldquo;SAM-e 100% active 400mg\/Capsule - 30 Capsules&rdquo; has been added to your cart\" role=\"button\"><span class=\"avia-svg-icon avia-font-svg_entypo-fontello\" data-av_svg_icon='basket' data-av_iconset='svg_entypo-fontello'><svg version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"29\" height=\"32\" viewBox=\"0 0 29 32\" preserveAspectRatio=\"xMidYMid meet\" aria-labelledby='av-svg-title-6' aria-describedby='av-svg-desc-6' role=\"graphics-symbol\" aria-hidden=\"true\">\n<title id='av-svg-title-6'>Add to cart<\/title>\n<desc id='av-svg-desc-6'>Add to cart<\/desc>\n<path d=\"M4.8 27.2q0-1.28 0.96-2.24t2.24-0.96q1.344 0 2.272 0.96t0.928 2.24q0 1.344-0.928 2.272t-2.272 0.928q-1.28 0-2.24-0.928t-0.96-2.272zM20.8 27.2q0-1.28 0.96-2.24t2.24-0.96q1.344 0 2.272 0.96t0.928 2.24q0 1.344-0.928 2.272t-2.272 0.928q-1.28 0-2.24-0.928t-0.96-2.272zM10.496 19.648q-1.152 0.32-1.088 0.736t1.408 0.416h17.984v2.432q0 0.64-0.64 0.64h-20.928q-0.64 0-0.64-0.64v-2.432l-0.32-1.472-3.136-14.528h-3.136v-2.56q0-0.64 0.64-0.64h4.992q0.64 0 0.64 0.64v2.752h22.528v8.768q0 0.704-0.576 0.832z\"><\/path>\n<\/svg><\/span>  Add to cart<\/a>\t<span id=\"woocommerce_loop_add_to_cart_link_describedby_7201\" class=\"screen-reader-text\">\n\t\t\t<\/span>\n<a class=\"button show_details_button\" href=\"https:\/\/nugenis.eu\/en\/produkt\/sam-e\/\"><span class=\"avia-svg-icon avia-font-svg_entypo-fontello\" data-av_svg_icon='doc-text' data-av_iconset='svg_entypo-fontello'><svg version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"22\" height=\"32\" viewBox=\"0 0 22 32\" preserveAspectRatio=\"xMidYMid meet\" aria-labelledby='av-svg-title-7' aria-describedby='av-svg-desc-7' role=\"graphics-symbol\" aria-hidden=\"true\">\n<title id='av-svg-title-7'>Show Details<\/title>\n<desc id='av-svg-desc-7'>Show Details<\/desc>\n<path d=\"M6.784 17.344v-2.88h8.96v2.88h-8.96zM19.2 1.6q1.344 0 2.272 0.928t0.928 2.272v22.4q0 1.28-0.928 2.24t-2.272 0.96h-16q-1.28 0-2.24-0.96t-0.96-2.24v-22.4q0-1.344 0.96-2.272t2.24-0.928h16zM19.2 27.2v-22.4h-16v22.4h16zM15.68 8.256v2.816h-8.96v-2.816h8.96zM15.68 20.8v2.816h-8.96v-2.816h8.96z\"><\/path>\n<\/svg><\/span>  Show Details<\/a> <span class=\"button-mini-delimiter\"><\/span><\/div><\/div><\/li>\n<\/ul><\/div><\/div><div class=\"clear\"><\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-rc78-0d0c101cc64c990add8188a2feac188b\">\n.flex_column.av-rc78-0d0c101cc64c990add8188a2feac188b{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-rc78-0d0c101cc64c990add8188a2feac188b av_one_fourth flex_column_div av-zero-column-padding  '     ><\/div>\n<\/div><\/div><\/div><!-- close content main div --><\/div><\/div><div id='after_section_5'  class='main_color av_default_container_wrap container_wrap sidebar_right'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-524'><div class='entry-content-wrapper clearfix'>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":4597,"parent":0,"menu_order":340,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-524","page","type-page","status-publish","has-post-thumbnail","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.2 (Yoast SEO v27.9) - 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