{"id":539,"date":"2016-11-16T13:16:28","date_gmt":"2016-11-16T12:16:28","guid":{"rendered":"https:\/\/nugenis.eu\/?page_id=539&#038;lang=en"},"modified":"2025-05-06T12:49:58","modified_gmt":"2025-05-06T10:49:58","slug":"research","status":"publish","type":"page","link":"https:\/\/nugenis.eu\/en\/research\/","title":{"rendered":"Research"},"content":{"rendered":"\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_section-cf922057356556c031cf56eacae05847\">\n.avia-section.av-av_section-cf922057356556c031cf56eacae05847{\nbackground-repeat:no-repeat;\nbackground-image:url(https:\/\/nugenis.eu\/wp-content\/uploads\/2016\/08\/Nugenis_home2-1500x430.jpg);\nbackground-position:0% 0%;\nbackground-attachment:scroll;\n}\n.avia-section.av-av_section-cf922057356556c031cf56eacae05847 .av-section-color-overlay{\nopacity:0.5;\nbackground-color:#000000;\nbackground-image:url(https:\/\/nugenis.eu\/wp-content\/themes\/nugenis\/images\/background-images\/grain_top.png);\nbackground-repeat:repeat;\n}\n<\/style>\n<div id='av_section_1'  class='avia-section av-av_section-cf922057356556c031cf56eacae05847 main_color avia-section-default avia-no-shadow  avia-builder-el-0  el_before_av_section  avia-builder-el-first  avia-full-stretch avia-bg-style-scroll av-section-color-overlay-active av-minimum-height av-minimum-height-25 av-height-25  container_wrap sidebar_right'  data-section-bg-repeat='stretch' data-av_minimum_height_pc='25' data-av_min_height_opt='25'><div class=\"av-section-color-overlay-wrap\"><div class=\"av-section-color-overlay\"><\/div><a href='#next-section' title='' class='scroll-down-link  avia-svg-icon avia-font-svg_entypo-fontello' data-av_svg_icon='down-open-mini' data-av_iconset='svg_entypo-fontello'><svg version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"15\" height=\"32\" viewBox=\"0 0 15 32\" preserveAspectRatio=\"xMidYMid meet\" aria-labelledby='av-svg-title-1' aria-describedby='av-svg-desc-1' role=\"graphics-symbol\" aria-hidden=\"true\">\n<title id='av-svg-title-1'>Scroll to next section<\/title>\n<desc id='av-svg-desc-1'>Scroll to next section<\/desc>\n<path d=\"M12.96 12.16q0.704-0.832 1.536 0 0.832 0.704 0 1.536l-6.272 6.144q-0.704 0.704-1.536 0l-6.272-6.144q-0.832-0.832 0-1.536 0.768-0.768 1.6 0l5.44 4.992z\"><\/path>\n<\/svg><\/a><div class='container av-section-cont-open' ><main  role=\"main\" itemprop=\"mainContentOfPage\"  class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-539'><div class='entry-content-wrapper clearfix'>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_heading-7f628056f0b19a5fd5e5c61fcffb1431\">\n#top .av-special-heading.av-av_heading-7f628056f0b19a5fd5e5c61fcffb1431{\npadding-bottom:10px;\ncolor:#ffffff;\n}\nbody .av-special-heading.av-av_heading-7f628056f0b19a5fd5e5c61fcffb1431 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-av_heading-7f628056f0b19a5fd5e5c61fcffb1431 .special-heading-inner-border{\nborder-color:#ffffff;\n}\n.av-special-heading.av-av_heading-7f628056f0b19a5fd5e5c61fcffb1431 .av-subheading{\nfont-size:20px;\n}\n<\/style>\n<div  class='av-special-heading av-av_heading-7f628056f0b19a5fd5e5c61fcffb1431 av-special-heading-h1 custom-color-heading blockquote modern-quote modern-centered  avia-builder-el-1  el_before_av_hr  avia-builder-el-first '><h1 class='av-special-heading-tag '  itemprop=\"headline\"  >NUGENIS &#8211; Touchpoint Epigenetics<\/h1><div class='av_custom_color av-subheading av-subheading_below'><p>Recent Findings of Research<\/p>\n<\/div><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div>\n<div  class='hr av-av_hr-bad5bc90bcef2f12297bff634a297b07 hr-short  avia-builder-el-2  el_after_av_heading  avia-builder-el-last  hr-center'><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n\n<\/div><\/div><\/main><!-- close content main element --><\/div><\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_section-31ce7de6df4c0bc175c089a641e79f7f\">\n.avia-section.av-av_section-31ce7de6df4c0bc175c089a641e79f7f{\nbackground-color:#ffffff;\nbackground-image:unset;\n}\n<\/style>\n<div id='av_section_2'  class='avia-section av-av_section-31ce7de6df4c0bc175c089a641e79f7f main_color avia-section-default avia-no-border-styling  avia-builder-el-3  el_after_av_section  el_before_av_section  avia-bg-style-scroll container_wrap sidebar_right'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-539'><div class='entry-content-wrapper clearfix'>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_heading-29a37b72d443226b892e117b7119547d\">\n#top .av-special-heading.av-av_heading-29a37b72d443226b892e117b7119547d{\npadding-bottom:10px;\n}\nbody .av-special-heading.av-av_heading-29a37b72d443226b892e117b7119547d .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-av_heading-29a37b72d443226b892e117b7119547d .av-subheading{\nfont-size:20px;\n}\n<\/style>\n<div  class='av-special-heading av-av_heading-29a37b72d443226b892e117b7119547d av-special-heading-h2 blockquote modern-quote modern-centered  avia-builder-el-4  el_before_av_hr  avia-builder-el-first '><h2 class='av-special-heading-tag '  itemprop=\"headline\"  >RESEARCH<\/h2><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_hr-a6de236e6c183bbbd700292deacd2b52\">\n#top .hr.hr-invisible.av-av_hr-a6de236e6c183bbbd700292deacd2b52{\nheight:20px;\n}\n<\/style>\n<div  class='hr av-av_hr-a6de236e6c183bbbd700292deacd2b52 hr-invisible  avia-builder-el-5  el_after_av_heading  el_before_av_three_fifth '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_three_fifth-ccc41b1437e8ef8415a8890f7fa1a952\">\n.flex_column.av-av_three_fifth-ccc41b1437e8ef8415a8890f7fa1a952{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-av_three_fifth-ccc41b1437e8ef8415a8890f7fa1a952 av_three_fifth  avia-builder-el-6  el_after_av_hr  el_before_av_two_fifth  first flex_column_div av-animated-generic left-to-right av-zero-column-padding  '     ><section  class='av_textblock_section av-av_textblock-0366cc7376be6c9e82a3e9cc8987b64f '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p style=\"text-align: justify;\"><strong>NUGENIS<\/strong> wants to promote research into applied epigenetics. We are open to share our knowledge and promote exchange on a professional level. We are happy to support young scientists deciding on their research topic with ideas and contacts to research groups.<\/p>\n<p style=\"text-align: justify;\">We are looking forward to your scientific questions under <a href=\"&#x6d;a&#x69;l&#x74;&#111;&#x3a;&#111;f&#x66;i&#x63;&#101;&#x40;&#110;&#x75;&#103;e&#x6e;i&#x73;&#46;&#x65;&#117;\" target=\"_top\">&#x6f;&#x66;&#102;i&#x63;&#x65;&#x40;&#110;u&#x67;&#x65;&#x6e;&#105;s&#x2e;&#x65;&#x75;<\/a><\/p>\n<\/div><\/section><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_two_fifth-5d86e5d684d9f93324bdd977194749d3\">\n.flex_column.av-av_two_fifth-5d86e5d684d9f93324bdd977194749d3{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-av_two_fifth-5d86e5d684d9f93324bdd977194749d3 av_two_fifth  avia-builder-el-8  el_after_av_three_fifth  el_before_av_heading  flex_column_div av-animated-generic right-to-left av-zero-column-padding  '     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_image-4bd7d3ee015574af192d51ab3c85a902\">\n.avia-image-container.av-av_image-4bd7d3ee015574af192d51ab3c85a902 img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-av_image-4bd7d3ee015574af192d51ab3c85a902 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-av_image-4bd7d3ee015574af192d51ab3c85a902 av-styling- av-hover-grow av-img-linked avia_animated_image av-animated-when-visible-95 fade-in avia-align-center  avia-builder-el-9  avia-builder-el-no-sibling '   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><a href=\"https:\/\/nugenis.eu\/wp-content\/uploads\/2016\/11\/dna-methyl-e-1030x580.png\" data-srcset=\"https:\/\/nugenis.eu\/wp-content\/uploads\/2016\/11\/dna-methyl-e-1030x580.png 1030w, https:\/\/nugenis.eu\/wp-content\/uploads\/2016\/11\/dna-methyl-e-450x253.png 450w, https:\/\/nugenis.eu\/wp-content\/uploads\/2016\/11\/dna-methyl-e-300x169.png 300w, https:\/\/nugenis.eu\/wp-content\/uploads\/2016\/11\/dna-methyl-e-768x432.png 768w, https:\/\/nugenis.eu\/wp-content\/uploads\/2016\/11\/dna-methyl-e-1500x844.png 1500w, https:\/\/nugenis.eu\/wp-content\/uploads\/2016\/11\/dna-methyl-e-705x397.png 705w, https:\/\/nugenis.eu\/wp-content\/uploads\/2016\/11\/dna-methyl-e.png 1921w\" data-sizes=\"(max-width: 1030px) 100vw, 1030px\" class='avia_image '  aria-label='DNA Methylation - NUGENIS supports the DNA Methylation with Applied Epigenetics'><img decoding=\"async\" fetchpriority=\"high\" class='wp-image-2819 avia-img-lazy-loading-not-2819 avia_image ' src=\"https:\/\/nugenis.eu\/wp-content\/uploads\/2016\/11\/dna-methyl-e.png\" alt='DNA Methylation - NUGENIS supports the DNA Methylation with Applied Epigenetics' title='DNA Methylation - NUGENIS supports the DNA Methylation with Applied Epigenetics'  height=\"1081\" width=\"1921\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/nugenis.eu\/wp-content\/uploads\/2016\/11\/dna-methyl-e.png 1921w, https:\/\/nugenis.eu\/wp-content\/uploads\/2016\/11\/dna-methyl-e-450x253.png 450w, https:\/\/nugenis.eu\/wp-content\/uploads\/2016\/11\/dna-methyl-e-300x169.png 300w, https:\/\/nugenis.eu\/wp-content\/uploads\/2016\/11\/dna-methyl-e-768x432.png 768w, https:\/\/nugenis.eu\/wp-content\/uploads\/2016\/11\/dna-methyl-e-1030x580.png 1030w, https:\/\/nugenis.eu\/wp-content\/uploads\/2016\/11\/dna-methyl-e-1500x844.png 1500w, https:\/\/nugenis.eu\/wp-content\/uploads\/2016\/11\/dna-methyl-e-705x397.png 705w\" sizes=\"(max-width: 1921px) 100vw, 1921px\" \/><\/a><\/div><\/div><\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_heading-03ef782c4863fe86e7bea72823073bb4\">\n#top .av-special-heading.av-av_heading-03ef782c4863fe86e7bea72823073bb4{\npadding-bottom:10px;\n}\nbody .av-special-heading.av-av_heading-03ef782c4863fe86e7bea72823073bb4 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-av_heading-03ef782c4863fe86e7bea72823073bb4 .av-subheading{\nfont-size:20px;\n}\n<\/style>\n<div  class='av-special-heading av-av_heading-03ef782c4863fe86e7bea72823073bb4 av-special-heading-h2 blockquote modern-quote  avia-builder-el-10  el_after_av_two_fifth  el_before_av_two_fifth '><h2 class='av-special-heading-tag '  itemprop=\"headline\"  >SCIENTIFIC BACKGROUND<\/h2><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_two_fifth-ccc41b1437e8ef8415a8890f7fa1a952\">\n.flex_column.av-av_two_fifth-ccc41b1437e8ef8415a8890f7fa1a952{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-av_two_fifth-ccc41b1437e8ef8415a8890f7fa1a952 av_two_fifth  avia-builder-el-11  el_after_av_heading  avia-builder-el-last  first flex_column_div av-animated-generic left-to-right av-zero-column-padding  '     ><p><div  class='avia-video av-av_video-7d521410a74785f9a3db28e5f1af8a3a avia-video-16-9 av-no-preview-image avia-video-load-always av-lazyload-immediate av-lazyload-video-embed'  itemprop=\"video\" itemtype=\"https:\/\/schema.org\/VideoObject\"  data-original_url='https:\/\/www.youtube.com\/watch?v=ReCvreRPdeY'><script type='text\/html' class='av-video-tmpl'><div class='avia-iframe-wrap'><iframe loading=\"lazy\" width=\"1500\" height=\"844\" src=\"https:\/\/www.youtube.com\/embed\/ReCvreRPdeY?feature=oembed&autoplay=0&loop=0&controls=1&mute=0\" frameborder=\"0\" allowfullscreen><\/iframe><\/div><\/script><div class='av-click-to-play-overlay'><div class=\"avia_playpause_icon\"><\/div><\/div><\/div><br \/>\n<div  class='avia-video av-av_video-e9a620e972e23da239be851a8525755b avia-video-16-9 av-no-preview-image avia-video-load-always av-lazyload-immediate av-lazyload-video-embed'  itemprop=\"video\" itemtype=\"https:\/\/schema.org\/VideoObject\"  data-original_url='https:\/\/www.youtube.com\/watch?v=JTBg6hqeuTg'><script type='text\/html' class='av-video-tmpl'><div class='avia-iframe-wrap'><iframe loading=\"lazy\" width=\"1500\" height=\"844\" src=\"https:\/\/www.youtube.com\/embed\/JTBg6hqeuTg?feature=oembed&autoplay=0&loop=0&controls=1&mute=0\" frameborder=\"0\" allowfullscreen><\/iframe><\/div><\/script><div class='av-click-to-play-overlay'><div class=\"avia_playpause_icon\"><\/div><\/div><\/div><\/p><\/div>\n\n<\/div><\/div><\/div><!-- close content main div --><\/div><\/div><div id='av_section_3'  class='avia-section av-av_section-915b33fd1d6006bfc684ade488387eaf main_color avia-section-default avia-no-border-styling  avia-builder-el-14  el_after_av_section  avia-builder-el-last  avia-bg-style-scroll container_wrap sidebar_right'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-539'><div class='entry-content-wrapper clearfix'>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_heading-c76b54dbd79b511c79b77f95600cdbd0\">\n#top .av-special-heading.av-av_heading-c76b54dbd79b511c79b77f95600cdbd0{\npadding-bottom:15px;\n}\nbody .av-special-heading.av-av_heading-c76b54dbd79b511c79b77f95600cdbd0 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-av_heading-c76b54dbd79b511c79b77f95600cdbd0 .av-subheading{\nfont-size:14px;\n}\n<\/style>\n<div  class='av-special-heading av-av_heading-c76b54dbd79b511c79b77f95600cdbd0 av-special-heading-h3 blockquote modern-quote  avia-builder-el-15  el_before_av_one_half  avia-builder-el-first '><h3 class='av-special-heading-tag '  itemprop=\"headline\"  >Further recommended reading on this topic<\/h3><div class='av-subheading av-subheading_below'><p>(August 2016)<\/p>\n<\/div><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_one_half-48fa403461522c90ad195d35fed0c7d4\">\n.flex_column.av-av_one_half-48fa403461522c90ad195d35fed0c7d4{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-av_one_half-48fa403461522c90ad195d35fed0c7d4 av_one_half  avia-builder-el-16  el_after_av_heading  el_before_av_one_half  first flex_column_div av-animated-generic fade-in av-zero-column-padding  '     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_textblock-4be7e3e0d88a6602c45b69434efeb1b1\">\n#top .av_textblock_section.av-av_textblock-4be7e3e0d88a6602c45b69434efeb1b1 .avia_textblock{\nfont-size:13px;\n}\n<\/style>\n<section  class='av_textblock_section av-av_textblock-4be7e3e0d88a6602c45b69434efeb1b1 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p style=\"text-align: justify;\">Bottiglieri T, Reynolds EH, Toone BK, Carney MW. CSF S-adenosylmethionine in neuropsychiatric disorders. Lancet 1991 Jul 13;338(8759):121<\/p>\n<p style=\"text-align: justify;\">Chan A, Remington R, Kotyla E, Lepore A, Zemianek J, Shea TB. A vitamin\/nutriceutical formulation improves memory and cognitive performance in community-dwelling adults without dementia. J Nutr Health Aging 2010 Mar;14(3):224-30<\/p>\n<p style=\"text-align: justify;\">Chouliaras L, Rutten BP, Kenis G, Peerbooms O, Visser PJ, Verhey F, et al. Epigenetic regulation in the pathophysiology of Alzheimer&#8217;s disease. Prog Neurobiol 2010 Apr;90(4):498-510<\/p>\n<p style=\"text-align: justify;\">de Jager CA, Oulhaj A, Jacoby R, Refsum H, Smith AD. Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial. Int J Geriatr Psychiatry 2011 Jul 21<\/p>\n<p style=\"text-align: justify;\">Fontanari D, Di Palma C, Giorgetti G, Violante F, Voltolina M. Effects of S-adenosyl-L-methionine on cognitive and vigilance functions in the elderly. Current Therapeutic Research 55 [6], 682-689. 1994<\/p>\n<p style=\"text-align: justify;\">Fuso A, Nicolia V, Ricceri L, Cavallaro RA, Isopi E, Mangia F, et al. S-adenosylmethionine reduces the progress of the Alzheimer-like features induced by B-vitamin deficiency in mice. Neurobiol Aging 2012 Jan 4.<\/p>\n<p style=\"text-align: justify;\">Fuso A, Scarpa S. One-carbon metabolism and Alzheimer&#8217;s disease: is it all a methylation matter? Neurobiol Aging 2011 Jul;32(7):1192-5<\/p>\n<p style=\"text-align: justify;\">Fuso A, Seminara L, Cavallaro RA, D&#8217;Anselmi F, Scarpa S. S-adenosylmethionine\/homocysteine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-amyloid production. Mol Cell Neurosci 2005 Jan;28(1):195-204<\/p>\n<p style=\"text-align: justify;\">Goren JL, Stoll AL, Damico KE, Sarmiento IA, Cohen BM. Bioavailability and lack of toxicity of S-adenosyl-L-methionine (SAMe) in humans. Pharmacotherapy 2004 Nov;24(11):1501-7<\/p>\n<p style=\"text-align: justify;\">Levkovitz Y, Alpert JE, Brintz CE, Mischoulon D, Papakostas GI. Effects of S-adenosylmethionine augmentation of serotonin-reuptake inhibitor antidepressants on cognitive symptoms of major depressive disorder. J Affect Disord 2012 Feb;136(3):1174-8<\/p>\n<\/div><\/section><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_one_half-30345572d6c06d9cfd42ea37ace6bad0\">\n.flex_column.av-av_one_half-30345572d6c06d9cfd42ea37ace6bad0{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-av_one_half-30345572d6c06d9cfd42ea37ace6bad0 av_one_half  avia-builder-el-18  el_after_av_one_half  el_before_av_one_half  flex_column_div av-animated-generic fade-in av-zero-column-padding  '     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_textblock-4be7e3e0d88a6602c45b69434efeb1b1\">\n#top .av_textblock_section.av-av_textblock-4be7e3e0d88a6602c45b69434efeb1b1 .avia_textblock{\nfont-size:13px;\n}\n<\/style>\n<section  class='av_textblock_section av-av_textblock-4be7e3e0d88a6602c45b69434efeb1b1 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p style=\"text-align: justify;\">Mastroeni D, Grover A, Delvaux E, Whiteside C, Coleman PD, Rogers J. Epigenetic changes in Alzheimer&#8217;s disease: decrements in DNA methylation. Neurobiol Aging 2010 Dec;31(12):2025-37<\/p>\n<p style=\"text-align: justify;\">Refsum H, Smith AD. Low vitamin B-12 status in confirmed Alzheimer&#8217;s disease as revealed by serum holotranscobalamin. J Neurol Neurosurg Psychiatry 2003 Jul;74(7):959-61<\/p>\n<p style=\"text-align: justify;\">Remington R, Lortie JJ, Hoffmann H, Page R, Morrell C, Shea TB. A Nutritional Formulation for Cognitive Performance in Mild Cognitive Impairment: A Placebo-Controlled Trial with an Open-Label Extension. J Alzheimers Dis. 2015 Oct 1;48(3):591-5<\/p>\n<p style=\"text-align: justify;\">Remington R, Chan A, Paskavitz J, Shea TB. Efficacy of a vitamin\/nutriceutical formulation for moderate-stage to later-stage Alzheimer&#8217;s disease: a placebo-controlled pilot study. Am J Alzheimers Dis Other Demen 2009 Feb;24(1):27-33<\/p>\n<p style=\"text-align: justify;\">Thompson MA, Bauer BA, Loehrer LL, Cha SS, Mandrekar JN, Sood A, et al. Dietary supplement S-adenosyl-L-methionine (AdoMet) effects on plasma homocysteine levels in healthy human subjects: a double-blind, placebo-controlled, randomized clinical trial. J Altern Complement Med 2009 May;15(5):523-9<\/p>\n<p style=\"text-align: justify;\">Wang SC, Oelze B, Schumacher A. Age-specific epigenetic drift in late-onset Alzheimer&#8217;s disease. PLoS One 2008;3(7):e2698<\/p>\n<p style=\"text-align: justify;\">Zellner M, Baureder M, Rappold E, Bugert P, Kotzailias N, Babeluk R, et al. Comparative platelet proteome analysis reveals an increase of monoamine oxidase-B protein expression in Alzheimer&#8217;s disease but not in non-demented Parkinson&#8217;s disease patients. J Proteomics 2012 Jan 17.<\/p>\n<p style=\"text-align: justify;\">Zellner M, Babeluk R, Jakobsen LH, Gerner C, Umlauf E, Volf I, et al. A proteomics study reveals a predominant change in MaoB expression in platelets of healthy volunteers after high protein meat diet: relationship to the methylation cycle. J Neural Transm 2011 May;118(5):653-62<\/p>\n<\/div><\/section><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_one_half-48fa403461522c90ad195d35fed0c7d4\">\n.flex_column.av-av_one_half-48fa403461522c90ad195d35fed0c7d4{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-av_one_half-48fa403461522c90ad195d35fed0c7d4 av_one_half  avia-builder-el-20  el_after_av_one_half  el_before_av_one_half  first flex_column_div av-animated-generic fade-in av-zero-column-padding  column-top-margin'     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_textblock-4be7e3e0d88a6602c45b69434efeb1b1\">\n#top .av_textblock_section.av-av_textblock-4be7e3e0d88a6602c45b69434efeb1b1 .avia_textblock{\nfont-size:13px;\n}\n<\/style>\n<section  class='av_textblock_section av-av_textblock-4be7e3e0d88a6602c45b69434efeb1b1 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3 style=\"text-align: justify;\"><\/h3>\n<h4>Monoamine oxidase B concentration increased to a pathological level has also been seen in these patients:<\/h4>\n<p><strong>Smokers<\/strong><\/p>\n<p style=\"text-align: justify;\">Launay J-M, Del Pino M, Chironi G, et al. Smoking Induces Long-Lasting Effects through a Monoamine-Oxidase Epigenetic Regulation. Tailleux L, ed. PLoS ONE. 2009;4(11):e7959 [<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2775922\" target=\"_blank\" rel=\"noopener\">http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2775922<\/a>]<\/p>\n<p style=\"text-align: justify;\"><strong>People on long-term medication with proton pump inhibitors (PPI) to block stomach acid<\/strong><\/p>\n<p style=\"text-align: justify;\">Haenisch B, von Holt K, Wiese B, Prokein J, Lange C, Ernst A, Brettschneider C, K\u00f6nig HH, Werle J, Weyerer S, Luppa M, Riedel-Heller SG, Fuchs A, Pentzek M, Weeg D, Bickel H, Broich K, Jessen F, Maier W, Scherer M. Risk of dementia in elderly patients with the use of proton pump inhibitors. Eur Arch Psychiatry Clin Neurosci. 2015 Aug;265(5):419-28 [<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25341874\" target=\"_blank\" rel=\"noopener\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25341874<\/a>]<\/p>\n<p style=\"text-align: justify;\"><strong>Possible pathomechanisms of homocysteine in the brain \u2013 hyperphosphorylated tau protein<\/strong><\/p>\n<p style=\"text-align: justify;\">Hara J, Shankle WR, Barrentine LW, Curole MV. Novel Therapy of Homocysteinemia in Mild Cognitive Impairment, Alzheimer&#8217;s Disease, and Other Dementing Disorders. J Nutrition Health Aging 2016; 20(8): 825-834 <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27709231\">[http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27709231]\u00a0<\/a><\/p>\n<p style=\"text-align: justify;\">Linnebank M, Popp J, Smulders Y, Smith D, Semmler A, Farkas M, Kulic L, Cvetanovska G, Blom H, Stoffel-Wagner B, K\u00f6lsch H, Weller M, Jessen F. S-adenosylmethionine is decreased in the cerebrospinal fluid of patients with Alzheimer&#8217;s disease. Neurodegener Dis 2010;7(6):373-8 [<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20523031\" target=\"_blank\" rel=\"noopener\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20523031<\/a>]<\/p>\n<p style=\"text-align: justify;\">Popp J, Lewczuk P, Linnebank M, Cvetanovska G, Smulders Y, K\u00f6lsch H, Frommann I, Kornhuber J, Maier W, Jessen F. Homocysteine metabolism and cerebrospinal fluid markers for Alzheimer&#8217;s disease. J Alzheimers Dis 2009;18(4):819-28 [<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19661622\" target=\"_blank\" rel=\"noopener\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19661622<\/a>]<\/p>\n<p style=\"text-align: justify;\">Siuda J, Gorzkowska A, Patalong-Ogiewa M, Kryzystanek E, Czech E, Wiechula B, Garczorz W, Danch A, Jasinska-Myga B, Opala G. From mild cognitive impairment to Alzheimer&#8217;s disease &#8211; influence of homocysteine, vitamin B12 and folate on cognition over time: results from one-year follow-up. Neurol Neurochir Pol 2009, Jul-Aug; 43(4):321-329 <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19742390\">[http:\/\/www.ncbi.nlm.nhi.gov\/pubmed\/19742390]<\/a><\/p>\n<p style=\"text-align: justify;\">Smith DE, Smulders YM, Blom HJ, Popp J, Jessen F, Semmler A, Farkas M, Linnebank M. Determinants of the essential one-carbon metabolism metabolites, homocysteine, S-adenosylmethionine, S-adenosylhomocysteine and folate, in cerebrospinal fluid. Clin Chem Lab Med 2012, 50(9):1641-7 [<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22962226\" target=\"_blank\" rel=\"noopener\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22962226<\/a>]<\/p>\n<p style=\"text-align: justify;\">Sontag E, Nunbhakdi-Craig V, Sontag JM, Diaz-Arrastia R, Ogris E, Dayal S, Lentz SR, Arning E, Bottiglieri T Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation. J Neurosci 2007, 27(11).2751-9 [<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17360897\" target=\"_blank\" rel=\"noopener\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17360897<\/a>]<\/p>\n<p style=\"text-align: justify;\">Sontag E, Hladik C, Montgomery L, Luangpirom A, Mudrak I, Ogris E, White CL 3rd . Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis. J Neuropathol Exp Neurol 2004, 63(10).1080-91 [<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20523031\" target=\"_blank\" rel=\"noopener\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15535135<\/a>]<\/p>\n<\/div><\/section><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_one_half-30345572d6c06d9cfd42ea37ace6bad0\">\n.flex_column.av-av_one_half-30345572d6c06d9cfd42ea37ace6bad0{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-av_one_half-30345572d6c06d9cfd42ea37ace6bad0 av_one_half  avia-builder-el-22  el_after_av_one_half  avia-builder-el-last  flex_column_div av-animated-generic fade-in av-zero-column-padding  column-top-margin'     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mace0x79-27f992153d0bb40632db249fe4161eda\">\n#top .av_textblock_section.av-mace0x79-27f992153d0bb40632db249fe4161eda .avia_textblock{\nfont-size:13px;\n}\n<\/style>\n<section  class='av_textblock_section av-mace0x79-27f992153d0bb40632db249fe4161eda '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3 style=\"text-align: justify;\"><\/h3>\n<h4 style=\"text-align: justify;\">Think about your brain:<\/h4>\n<div class=\"cover-image__parent-item\">\n<p><span class=\"accordion-tabbed__tab-mobile accordion__closed\"><a id=\"a1_Ctrl\" class=\"author-name accordion-tabbed__control\" role=\"button\" href=\"https:\/\/alz-journals.onlinelibrary.wiley.com\/authored-by\/Ercan\/Huriye\" data-id=\"a1\" data-db-target-for=\"a1\" aria-controls=\"a1\" aria-haspopup=\"true\">Huriye Ercan<\/a><span class=\"comma-separator\">,\u00a0<\/span><\/span><span class=\"accordion-tabbed__tab-mobile accordion__closed\"><a id=\"a2_Ctrl\" class=\"author-name accordion-tabbed__control\" role=\"button\" href=\"https:\/\/alz-journals.onlinelibrary.wiley.com\/authored-by\/Reumiller\/Christina+Maria\" data-id=\"a2\" data-db-target-for=\"a2\" aria-controls=\"a2\" aria-haspopup=\"true\">Christina Maria Reumiller<\/a><span class=\"comma-separator\">,\u00a0<\/span><\/span><span class=\"accordion-tabbed__tab-mobile accordion__closed\"><a id=\"a3_Ctrl\" class=\"author-name accordion-tabbed__control\" role=\"button\" href=\"https:\/\/alz-journals.onlinelibrary.wiley.com\/authored-by\/M%C3%BChlberger\/Jacqueline\" data-id=\"a3\" data-db-target-for=\"a3\" aria-controls=\"a3\" aria-haspopup=\"true\">Jacqueline M\u00fchlberger<\/a><span class=\"comma-separator\">,\u00a0<\/span><\/span><span class=\"accordion-tabbed__tab-mobile accordion__closed\"><a id=\"a4_Ctrl\" class=\"author-name accordion-tabbed__control\" role=\"button\" href=\"https:\/\/alz-journals.onlinelibrary.wiley.com\/authored-by\/Hsu\/Felicia\" data-id=\"a4\" data-db-target-for=\"a4\" aria-controls=\"a4\" aria-haspopup=\"true\">Felicia Hsu<\/a><span class=\"comma-separator\">,\u00a0<\/span><\/span><span class=\"accordion-tabbed__tab-mobile accordion__closed\"><a id=\"a5_Ctrl\" class=\"author-name accordion-tabbed__control\" role=\"button\" href=\"https:\/\/alz-journals.onlinelibrary.wiley.com\/authored-by\/Schmidt\/Georg+Johannes\" data-id=\"a5\" data-db-target-for=\"a5\" aria-controls=\"a5\" aria-haspopup=\"true\">Georg Johannes Schmidt<\/a><span class=\"comma-separator\">,\u00a0<\/span><\/span><span class=\"accordion-tabbed__tab-mobile accordion__closed\"><a id=\"a6_Ctrl\" class=\"author-name accordion-tabbed__control\" role=\"button\" href=\"https:\/\/alz-journals.onlinelibrary.wiley.com\/authored-by\/Umlauf\/Ellen\" data-id=\"a6\" data-db-target-for=\"a6\" aria-controls=\"a6\" aria-haspopup=\"true\">Ellen Umlauf<\/a><span class=\"comma-separator\">,\u00a0<\/span><\/span><span class=\"accordion-tabbed__tab-mobile accordion__closed\"><a id=\"a7_Ctrl\" class=\"author-name accordion-tabbed__control\" role=\"button\" href=\"https:\/\/alz-journals.onlinelibrary.wiley.com\/authored-by\/Miller\/Ingrid\" data-id=\"a7\" data-db-target-for=\"a7\" aria-controls=\"a7\" aria-haspopup=\"true\">Ingrid Miller<\/a><span class=\"comma-separator\">,\u00a0<\/span><\/span><span class=\"accordion-tabbed__tab-mobile accordion__closed\"><a id=\"a8_Ctrl\" class=\"author-name accordion-tabbed__control\" role=\"button\" href=\"https:\/\/alz-journals.onlinelibrary.wiley.com\/authored-by\/Rappold\/Eduard\" data-id=\"a8\" data-db-target-for=\"a8\" aria-controls=\"a8\" aria-haspopup=\"true\">Eduard Rappold<\/a><span class=\"comma-separator\">,\u00a0<\/span><\/span><span class=\"accordion-tabbed__tab-mobile accordion__closed\"><a id=\"a9_Ctrl\" class=\"author-name accordion-tabbed__control\" role=\"button\" href=\"https:\/\/alz-journals.onlinelibrary.wiley.com\/authored-by\/Attems\/Johannes\" data-id=\"a9\" data-db-target-for=\"a9\" aria-controls=\"a9\" aria-haspopup=\"true\">Johannes Attems<\/a><span class=\"comma-separator\">,\u00a0<\/span><\/span><span class=\"accordion-tabbed__tab-mobile accordion__closed\"><a id=\"a10_Ctrl\" class=\"author-name accordion-tabbed__control\" role=\"button\" href=\"https:\/\/alz-journals.onlinelibrary.wiley.com\/authored-by\/Oehler\/Rudolf\" data-id=\"a10\" data-db-target-for=\"a10\" aria-controls=\"a10\" aria-haspopup=\"true\">Rudolf Oehler<\/a><span class=\"comma-separator\">,\u00a0<\/span><\/span><span class=\"accordion-tabbed__tab-mobile accordion__closed\"><a id=\"a11_Ctrl\" class=\"author-name accordion-tabbed__control\" role=\"button\" href=\"https:\/\/alz-journals.onlinelibrary.wiley.com\/authored-by\/Zellner\/Maria\" data-id=\"a11\" data-db-target-for=\"a11\" aria-controls=\"a11\" aria-haspopup=\"true\">Maria Zellner. <\/a><\/span>Platelets mirror changes in the frontal lobe antioxidant system in Alzheimer&#8217;s disease. Alzheimer&#8217;s &amp; Dementia: <span class=\"comma\">Volume 21,\u00a0<\/span>Issue 4. <span class=\"epub-state\">First published: <\/span><span class=\"epub-date\">06 April 2025. https:\/\/doi.org\/10.1002\/alz.7011<\/span><\/p>\n<\/div>\n<p style=\"text-align: justify;\"><strong>Mild brain injury<\/strong><\/p>\n<p style=\"text-align: justify;\">Yang, Shun-Tai et al. Accumulation of amyloid in cognitive impairment after mild traumatic brain injury. Journal of the Neurological Sciences , Volume 349, Issue 1, 99-104 [<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25586534\" target=\"_blank\" rel=\"noopener\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25586534<\/a>]<\/p>\n<p style=\"text-align: justify;\"><strong>Ingestion of aluminium<\/strong><\/p>\n<p style=\"text-align: justify;\">Singla N, Dhawan D.K. Zinc Improves Cognitive and Neuronal Dysfunction During Aluminium-Induced Neurodegeneration. Mol Neurobiol (2016) [<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26742519\" target=\"_blank\" rel=\"noopener\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26742519<\/a>]<\/p>\n<p style=\"text-align: justify;\"><strong>Ademetionine and its effects on sleep<\/strong><\/p>\n<p style=\"text-align: justify;\">Arnold, O. et al. Double-blind, placebo-controlled pharmacodynamic studies with a nutraceutical and a pharmaceutical dose of ademetionine (SAMe) in elderly subjects, utilizing EEG mapping and psychometry. European Neuropsychopharmacology , Volume 15, Issue 5, 533-543 [<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16046102\" target=\"_blank\" rel=\"noopener\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16046102<\/a>]<\/p>\n<\/div><\/section><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_hr-a6de236e6c183bbbd700292deacd2b52\">\n#top .hr.hr-invisible.av-av_hr-a6de236e6c183bbbd700292deacd2b52{\nheight:20px;\n}\n<\/style>\n<div  class='hr av-av_hr-a6de236e6c183bbbd700292deacd2b52 hr-invisible  avia-builder-el-24  el_after_av_textblock  el_before_av_textblock '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_textblock-4be7e3e0d88a6602c45b69434efeb1b1\">\n#top .av_textblock_section.av-av_textblock-4be7e3e0d88a6602c45b69434efeb1b1 .avia_textblock{\nfont-size:13px;\n}\n<\/style>\n<section  class='av_textblock_section av-av_textblock-4be7e3e0d88a6602c45b69434efeb1b1 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h4 style=\"text-align: justify;\">News from the 8th Clinical Trials on Alzheimer&#8217;s Disease (CTAD) Congress in Barcelona, Spain (2015)<\/h4>\n<p style=\"text-align: justify;\"><strong>Healthy lifestyle substantially reduce risks for cognitive decline during aging<\/strong><\/p>\n<p style=\"text-align: justify;\">A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial.<\/p>\n<p style=\"text-align: justify;\">Miia Kivipelto, Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland Karolinska Institute Center for Alzheimer Research, Stockholm, Sweden<\/p>\n<p style=\"text-align: justify;\">Aerobic Exercise reverse aging effects of the brain; 45-60 minutes, four times per week, after six months significant effects<\/p>\n<p style=\"text-align: justify;\">Laura Baker, Ph.D., principal investigator of the study and a cognitive neuroscientist at Wake Forest Baptist Medical Center<\/p>\n<p style=\"text-align: justify;\"><strong>Drug developments<\/strong><\/p>\n<p style=\"text-align: justify;\">Mao-B inhibitor sembragiline from Roche did not improve cognitive functions of AD patients but improves neuropsychiatric scores.<\/p>\n<p style=\"text-align: justify;\">Rachelle S Doody Alzheimer\u2019s Disease and Memory Disorders Center, Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA<\/p>\n<\/div><\/section><\/p><\/div><\/div><\/div><\/div><!-- close content main div --><\/div><\/div><div id='after_section_3'  class='main_color av_default_container_wrap container_wrap sidebar_right'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-539'><div class='entry-content-wrapper clearfix'>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":8247,"parent":0,"menu_order":420,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-539","page","type-page","status-publish","has-post-thumbnail","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.2 (Yoast SEO v27.9) - 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