Epigenetic Burnout Protector
Epigenetics Protects Against Burnout and Improves Resilience
In western societies, the last decades have seen a fantastic growth in the degree of freedom of how much each one of us can live their own life freely while traditional gender roles and social norms have been broken down. We are all confronted with a new source of discontentment: our own inability to make use of this new level of freedom and to make the right choices to create a meaningful life.
Self-responsibility, personal fulfilment, the quest for happiness and success are all objectives that each and every one of us aspires to in our modern society. Many fail and react with an emotional void, depression, lethargy and addictions to their perceived “failure” and call this burnout.
EBOP® – Epigenetic Burnout Protector
30 capsules protect for 30 days
Sick leave (days) taken linked directly to burnout syndrome in Germany in years 2004 to 2014 (male/female/total)
For a healthy brain in old age and in times of physical or mental stress, burnout prevention and strengthening of our individual resilience is most important on a personal level as well as for society as a whole.
In stress physiology, the primary response after encountering an attacker is “fight or flight”. Stress may be a threat, danger or an act of physical aggression. Our body has been programmed by evolution to survive a threating situation. The decision, how we can extract ourselves from a dangerous situation is made pre- and subconsciously. Under the influence of stress hormones, brain (perception) and body (reaction) co-operate in order to remove an organism from the source of a threat to ensure survival.
The successful conclusion of a stress situation determines whether it will be mentally rewarding or, if it was unsuccessful, result in disease.
MaoB (monoamine oxidase B) expression significantly increases with age. Even in the healthy, MaoB concentration is elevated in those aged 40 and above, resulting in insufficient levels of brain messengers dopamine and serotonin. It is important to maintain the supply of dopamine for a healthy brain metabolism in a physiological way. Dopamine is the neurotransmitter linked to emotions, motility, happiness and the reward system and is, directly and indirectly, involved in the modulation of the immune system.
The brain transmitter serotonin also acts like a GABA mimetic and reduces anxiety, acts as a relaxant and promotes good sleep.
Transmethylation
Success makes us healthier
A successful adaptation following a stress response results in a phase of post-stress relaxation. The levels of adrenaline/noradrenaline and cortisol will return to their respective pre-stress levels in the “winner”. Repeated successful handling of a stress situation even lowers the baseline level of noradrenaline, adrenaline and cortisol. That means that success makes us healthier. A low level of cortisol promotes good sleep and strengthens the immune system. A “winner” will remain calm and master new situations with confidence.
Cortisol activates MaoB gene expression
Monoamine oxidase B (MaoB) is the enzyme responsible for the degradation of brain transmitters dopamine, serotonin and noradrenalin. An increased level of degradation of dopamine and serotonin results in a deficiency of these substances with wide-ranging consequences. On the one hand, brain cells are not protection against the neurotoxic degradation products of dopamine and on the other hand, serotonin deficiency results in low mood.
Epigenetics and permanent stress
The often encountered pathological psychosocial stress of a “loser” has its roots in the constant subjective burden of increased alertness. Noradrenaline, adrenaline and cortisol levels are slightly but permanently increased. A phase of relaxation is absent. Increased heart rate, high blood pressure and a compromised immune system, all these have an impact on life expectancy. Fat-soluble cortisol easily passes through the blood/brain barrier and, because it also is a transcription factor, affects the expression of a many genes. Long-term social concerns will increase the production of heterochromatin in the nuclei of hippocampal neurones. Heterochromatin is a highly condensed form of chromatin (the material our chromosomes are made from) with a notably decreased level of transcription as many genes are “silcenced”. Another effect of an increased cortisol level is the inhibition of neurone generation (neurogenesis) in the subgranular zone of the dentate gyrus, the part of the hippocampus responsible for long-term memory.
An elementary level of protection can be achieved by regular supplementation with adequate amounts of ademetionine and vitamin B12. Both of these substances are present in EBOP® – Epigenetic Burnout Protector which helps us to bounce back from negative experiences with new achievements and so helps us to return to our usual abilities.
EBOP® – Epigenetic Burnout Protector
Contains these five naturally in our body occurring substances:
Ademetionine is a metabolic product that can be found in all cells in our body. After water and ATP, the universally available and immediately usable source of energy, it is the third most abundant molecule in our body. Its physiological level in the cell decreases continuously from age 50 onwards.
Vitamin B12 supports those metabolic processes in our brain cells important for maintaining a healthy nervous system and normal mental performance. Vitamin B12 is involved in ademetionine production.
Vitamin B6 contributes to healthy energy metabolism, promotes healthy protein metabolism and supports a healthy immune system.
Folic acid assists with normal amino acid synthesis and supports the dispositional supply of the essential amino acid methionine in the one-carbon metabolic cycle.
Folic acid is involved in normal homocysteine metabolism.
Folic acid is essential for good mental health as ATP-activated methionine is produced from dispositionally supplied methionine and is involved in epigenetic control mechanisms to maintain normal mental functions.
Folic acid contributes to a healthy immune system.
Zinc helps to protect cells from oxidative stress. Oxidative stress is the main cause of cell aging.
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Innovation
In 2015, NUGENIS was a awarded the gold medal at the most important international trade fair for “Ideas, Invention and New Products”, iENA , for EBP® Epigenetic Brain Protector as an outstanding contribution to the protection of our brain cells.