EBP® – Epigenetic Brain Protector

A dietary supplement in Applied Epigenetics featuring the S-enantiomer, the exclusively biologically active form of S-Adenosyl-L-Methionine as coated granules, along with essential vitamins and a trace element in preventive dosages encapsulated in enteric-coated capsules.

The EBP® – Epigenetic Brain Protector shields brain cells from cellular demise.

Ademetionine (S-Adenosylmethionine, abbreviated as SAMe) is, after ATP (Adenosine Triphosphate), the cellular energy carrier—the most crucial molecule participating in over 100 metabolic processes, safeguarding the cell. Ademetionine is the solitary methyl group donor for the DNA code, the blueprint of genetic material. Methionine Adenosyltransferase (MAT) is responsible for synthesizing S-Adenosylmethionine from Methionine and ATP, ensuring somatic tissue methylation for normal organism development, a vital aspect of cell survival.

S-Adenosylmethionine is indispensable for three main metabolic pathways:

1. Transmethylation: Methyl groups (-CH3) from S-Adenosylmethionine can reversibly attach to the 5′-position on the Cytosine ring of DNA, temporarily silencing genes without altering the DNA code.
2. Transsulfuration: Contributes to Glutathione synthesis, the most potent antioxidant protecting against oxidative cell damage.
3. Biosynthesis of Spermidine and Spermine: Through Aminopropylation.

S-Adenosylmethionine is now recognized as a key regulator for cell metabolism, proliferation, differentiation, apoptosis, and cell death. It plays a crucial role in protecting our mitochondria. Methylation of the MAO gene locus prevents Monoamine Oxidase overexpression, avoiding mitochondrial oxidative stress. Healthy mitochondria are synonymous with overall health. Mitochondria, crucial energy sources for metabolic processes, including S-Adenosylmethionine biosynthesis, are vital for the body’s well-being.

The EBP® – Epigenetic Brain Protector addresses neurodegeneration issues and protects against oxidative stress on the mitochondria.

As Wilhelm Busch said, “Das Gute – dieser Satz steht fest – ist stets das Böse, was man läßt” (“The good – this sentence holds true – is always the evil that one avoids”). Mitochondria, housing Monoamine Oxidase B (MAOB) on their outer membrane, catalyze the oxidative deamination of neurotransmitters, generating the highly reactive Hydroxyl Radical •OH. This radical reacts with surrounding macromolecules, such as lipids, proteins, and DNA, leading to oxidative damage and diverse cellular injuries. Studies reveal accelerated DNA methylation aging in neurons in advanced Alzheimer’s cases due to DNA hypomethylation. CpH methylation, as effective as CpG methylation, is associated with gene transcription suppression, impacting active enhancers and promoters, indicating its role in AD. AD neurons exhibit abnormal cell cycle re-entry, hyperstimulation of apoptotic and inflammatory pathways, contributing to neuronal death and cognitive symptoms. Aging, stress, and various environmental factors modulate our genes through epigenetic mechanisms.

S-Adenosylmethionine aids DNA methylation, ensuring “gene silencing” of Monoamine Oxidase B (MAOB) gene loci.

The EBP® – Epigenetic Brain Protector, with its active S-Adenosylmethionine form, shields brain cells and the blood-brain barrier endothelium. Monoamine Oxidase B (MAOB) is found in the outer mitochondrial membrane of dopaminergic neurons, influencing neurotransmitter metabolism. Increased MAOB expression disrupts the regulatory influence of protoplasmic astrocytes on endothelial cells, compromising the blood-brain barrier, leading to neuroinflammation.

Daily consumption of EBP® protects brain cells from neurodegeneration and neuroinflammation, promoting healthy aging. NUGENIS received the Gold Medal at iENA for the EBP® – Epigenetic Brain Protector, recognized for outstanding brain cell protection.

The EBP® – Epigenetic Brain Protector comprises naturally occurring substances:

Ademetionine (S-Adenosylmethionine): • Produced mainly in the liver, decreasing with age. • S-Adenosylmethionine deficiency leads to hypomethylation of DNA, causing diseases. We utilize ADOGRAN®, a coated granule of S-Adenosylmethionine, protecting its active form.

Vitamin B12: • Supports brain cell metabolism, maintaining normal nervous system and psychological functions. • Hydroxocobalamin in EBP® has the best depot effect in brain cells.

Folic Acid: • Contributes to amino acid synthesis, providing essential amino acid Methionine in the 1-carbon cycle. • Supports normal homocysteine metabolism, crucial for preventing hyperhomocysteinemia. • Essential for psychological function and immune system function. We use QUATREFOLIC®, the glucosamine salt of 5-Methyltetrahydrofolate, ensuring high bioavailability.

Vitamin B6: • Supports normal psychological function. • Contributes to normal homocysteine metabolism. • Reduces fatigue and tiredness. We use Vitamin B6 in its activated form, PYRIDOXAL-5-PHOSPHATE (P5P). Zinc: • Protects cells from oxidative stress, the primary cause of cellular aging. The combined action of Ademetionine, Hydroxocobalamin, QUATREFOLIC®, and Pyridoxal-5-Phosphate prevents an increase in blood homocysteine levels, crucial for physical and mental health safety.

In summary, the EBP® – Epigenetic Brain Protector is a comprehensive supplement designed to promote brain health and combat age-related issues by leveraging the power of applied epigenetics and naturally occurring substance

Note: This information is provided for educational purposes and does not substitute for professional medical advice. Always consult with healthcare providers for personalized guidance on health-related matters.

Copyright © Eduard Rappold 2024