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NUGENIS – Touchpoint Epigenetics

Applied Epigenetics for your health

EpiAge - Test-Kit

Test Kit




Liver Cells




BE HEALTHY and STAY HEALTHY is the ultimate ambition for all of us

A healthy cell is an essential requirement.

Unfortunately, diseases and ageing are the rule.

Ageing will be curable.

Latest scientific research suggests that using ademetionine as a supplement reduces age-related loss of memory.

„EBP – Epigenetic Brain Protector“ was developed based on these findings.

The expression of monoamine oxidase B (MAO B) is already increased in early adulthood (shown as red dots in the figure on the left) because the level of biosynthesis of ADEMETIONINE, the methyl group donor for DNA and histone (hereditary material), is reduced.

One effect of increased expression of MAO B is oxidative desamination of the principal brain neurotransmitters dopamine, serotonin, noradrenaline and adrenaline resulting in neuronal cell death in the brain caused by ROS (reactive oxygen species), a metabolic product which is highly aggressive towards neurones.

Figure: MAO-B is a flavin monoamine oxidase and is attached to the outer mitochondrial membrane. With increasing age and in patients suffering from Alzheimer’s dementia, MAO-B expression can be increased up to 5x caused by the age related deficiency of ademetionine. Ademetionine silences MAO-B expression and prevents an increase in the level of MAO-B. The continuous degradation of important neurotransmitters such as dopamine, serotonin, noradrenaline and adrenaline results in chronic neurotransmitter deficiency and has a negative impact on logical reasoning, emotions and behaviour. Degradation of neurotransmitters is accompanied by simultaneous production of reactive oxygen species (ROS), which is destructive to mitochondria and brain cells. The patient suffers from neurodegeneration. Often, more than 50% of functional brain cells have been irreversibly damaged at the time of the initial diagnosis of Alzheimer’s dementia. If this destruction were to be stopped by increasing MAO-B, neuroneogenesis in the hippo campus would result in production of „index“ neurones and cognitive abilities would improve.

Figure: On the left: a healthy brain. On the right: brain atrophy caused by MAO B related neurodegeneration

One important mechanism involved is the inhibition of the gene location of MAO B via methylation.

Copyright 2014 Dr. Eduard Rappold

Abb.: MAO B- Expressions- Stilllegung durch SAM=S-Adenosylmethionin=Ademetionin

This process is dependent on the availabilty ADEMETIONINE (S-adenosylmethionine), the methyl group donor for hereditary material. Improved brain performance after supplementation with ADEMETIONINE is described unanimously for those suffering from Alzheimer’s dementia or mild cognitive impairment.

Which factors impede cellular vitality, good health and longevity of an organism?

Cellular health is dependent on the number and state of health of mitochondria.

Mitochondrial health is dependent on two factors: firstly, an intact respiratory chain is neeed to supply the organism with sufficient energy rich ATP and, secondly, the production of ROS (reactive oxygen species) which are biologically highly aggressive molecules, which target and destroy cellular and mitochondrial macromolecules, mitochondrial and nuclear DNA, RNA, phospholipids and proteins.

Compounding the problem is, that CHRONIC STRESS, which is linked to a hyperactive HPA axis, increases monoamine oxidase (MAO) expression even more via increased glucocorticoid availability thereby intensifying mitochondrial dysfunction (epigenetically acquired mitochondriopathy).

Mitochondrial dysfunction is observed in many neurodegenerative diseases such as Huntington’s Disease (HD), Parkinson’s Disease (PD), Amyotrophic Lateral Sclerosis (ALS), stroke and epilepsy. In addition, research conducted in the last couple of years has suggested that mitochondrial dysfunction is also seen in psychiatric diseases such as bipolar disorder (BD) or depression and metabolic diseases like diabetes mellitus.

A deficiency of soy spermidine, contained in SPERMIDINE SOYUP SOYPOWDER, also results in a methylation deficit in hereditary substance because soy spermidine, just like ADEMETIONINE, is an epigentically active key molecule in metabolism and together with ADEMETIONINE (S-adenosyl-L-methionine) protects cellular health.

Metabolic diversity of ADEMETIONINE and SPERMIDINE

ADEMETIONINE is the sole methyl group donor (CH3 group donor) for DNA (hereditary material) and is also involved in hundreds more methylation processes, for example the biosynthesis of melatonin for a healthy sleep, of glutathione, the most effective intracellular antioxidant, of choline for the production of acetylcholine which is important for our memory, for biotin and alpha lipoic acid, and for creatinine and L-carnitine.

SPERMIDINE is also involved in methylation of genes and is a potent inducer of autophagy, a process with can be likened to a cellular cleansing mechanism and is used by cells to get rid of toxic waste products. Autophagy results in relief, better functionality and prolonged life time. Superfluous, excessive or damaged macromolecules (misfolded proteins, DNA, RNA), organelles and intracellular bacteria, viruses or other microorganisms are digested by hydrolytic enzymes in bag shaped structures called lysozymes.

Spermidine biosynthesis is also already reduced in young adults by a third. ADEMETIONINE (-)-s-adenosyl-L-methionine is also essential for SPERMIDINE biosynthesis.

That means, ADEMETIONINE (S-adenosyl-L-methionine) as well as SPERMIDINE must be supplemented in adults to protect cellular health.

Use our EPIAGE TEST to determine the methylation grade of your hereditary material and determine your true biological age with an amazing reliability of 0,96.