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    Health is everyone’s concern

NUGENIS – Touchpoint Epigenetics

Applied Epigenetics for your health

TAKE CARE OF YOUR HEALTH

STAY YOUNG AND WELL

Est. 2015 AUSTRIA

NUGENIS TOUCHPOINT EPIGENETICS

TAKE CARE OF YOUR HEALTH

Being healthy is our top priority.

Cell health is important.

Mitochondria health affects cell health.

Disease and aging are common.

WHAT DOES NUGENIS PROVIDE FOR HEALTHCARE?

Based on scientific principles and certified quality and product safety, NUGENIS is a leader with its products because:

Innovative and Unique

NUGENIS products are innovative and have unique features:

  • Centella Leaf Extract: A potent fountain of youth enzyme (telomerase) activator, promotes wound healing. inform you
  • SAM-e 100% Active: Contains the L/S enantiomer of (S/S)-S-Adenosylmethionine, which is essential for its effect due to its spatial structure. inform you
  • Spermidine 3mg/Capsule: With 60 capsules optimized for 6mg spermidine/day, covers the monthly requirement. inform you

Specialist in Spermidine Products

NUGENIS specializes in spermidine products for supplementation:

  • Soy Spermidine: SOYUP-Spermidine (soy powder + spermidine) :       inform you
  • Wheat Germ Spermidine: Spermidine 3mg/capsule, 60 capsules:      inform you

Applied Epigenetics

NUGENIS specializes in ademetionine (S-Adenosylmethionine, SAM-e) supplements:

  • GOLD MEDAL (iENA 2015) for the protection of body cells and mitochondria.
    • EBP – Epigenetic Brain Protector: Prevents neurodegeneration (dementia). inform you
    • EBOP – Epigenetic Burnout Protector: Has antidepressant effects, protects against burnout. inform you
    • ECP – Epigenetic Cartilage Protector: Protects and regenerates cartilage cells, has a pain-relieving effect. inform you
    • ELCP – Epigenetic Liver Cells Protector: Protects liver cells and ensures ademetionine production. inform you

The Gold Medal Principle

Fig.: Increased expression of Monoamine Oxidase B (MAO B) – RED DOTS in the left image

In early adulthood, the expression of Monoamine Oxidase B (MAO B) increases as the biosynthesis of (S/S)-S-Adenosylmethionine (SAM-e, ademetionine) is reduced. This deficiency leads to increased MAO B expression and neurodegenerative processes through the breakdown of important brain neurotransmitters.

Fig.: MAO B expression shutdown by SAM=S-Adenosylmethionine=Ademetionine

MAO (Monoamin-Oxidase)

One effect of increased expression of MAO B is oxidative desamination of the principal brain neurotransmitters dopamine, serotonin, noradrenaline, and adrenaline resulting in neuronal cell death in the brain caused by ROS (reactive oxygen species), a metabolic product that is highly aggressive towards neurones.

Figure: MAO-B belongs to the Flavin Monoamine Oxidases and adheres to the outer mitochondrial membrane. With increasing age and in patients with Alzheimer’s dementia, there is an increase in MAO B expression up to 5-fold, due to the age-dependent deficiency of (S/S)-S-Adenosylmethionine (SAM-e, Ademetionine). The role of (S/S)-S-Adenosylmethionine (SAM-e, Ademetionine) is to silence the MAO B expression at the gene locus and prevent the increase in MAO B expression and thus the rise in MAO B. The breakdown of important brain neurotransmitters such as dopamine, serotonin, norepinephrine, and adrenaline leads to a permanent neurotransmitter deficiency, deteriorating cognition, emotions, and actions. This neurotransmitter breakdown is accompanied by the production of reactive oxygen species (ROS) and is destructive to mitochondria and brain cells. This leads to neurodegeneration and mitochondrial loss. Thus, at the clinical initial diagnosis of Alzheimer’s dementia, a significant portion of functional brain cells is irreparably destroyed. If this destruction caused by increased MAO B can be halted by (S/S)-S-Adenosylmethionine (SAM-e, ADEMETIONINE) supplementation, there is a possibility that cognitive brain function may improve through neurogenesis, generating “index” neurons in the hippocampus.

Mechanisms and Effects:

  • Neurodegeneration: Increased MAO B expression leads to neuronal cell death in the brain and a deficiency of dopamine, serotonin, norepinephrine, and adrenaline.
  • Mitochondrial Loss: Oxidative stress from reactive oxygen species (ROS) damages cells.

Compounding the problem is, that CHRONIC STRESS, which is linked to a hyperactive HPA axis, increases monoamine oxidase (MAO) expression even more via increased glucocorticoid availability thereby intensifying mitochondrial dysfunction (epigenetically acquired mitochondriopathy).

Cell Health and Longevity

Cell health depends on the number and health of mitochondria. Chronic stress and an overactive HPA axis amplify mitochondrial dysfunctions.

Relevant Diseases:

  • Neurodegenerative Diseases: Huntington’s, Parkinson’s, Alzheimer’s, ALS, stroke, epilepsy.
  • Psychiatric and Metabolic Diseases: Bipolar disorder, depression, diabetes mellitus.

Supplementation Required

Even in early adulthood, supplementation with (S/S)-S-Adenosylmethionine (SAM-e) and spermidine is necessary to maintain cell health.

EPIAGE Test

With the EPIAGE test, you can determine the methylation status of your genetic material and your true biological age with high accuracy. inform you

Note: This information is provided for educational purposes and does not replace professional medical advice. Always consult healthcare providers for individual advice on health-related questions.

Copyright © Eduard Rappold 2024

NUGENIS PRODUCTS – ORDER

Conveniently order from our online shop

EBP

Epigenetic

Brain

Protector

EBP

Epigenetic

Burnout

Protector

Epigenetic Arthrosis Protector (EAP™)

Epigenetic

Cartilage

Protector

ELCP

Epigenetic

Liver Cells

Protector

SAM-e

100% active

400 mg

Centella

Leaf Extract

300 mg

Spermidin

Wheat Germ Extract

3 mg

SoyUp

Spermidine

Soy Powder