Abstract:
EBP® – Epigenetic Brain Protector is a dietary supplement grounded in applied epigenetics, featuring S-Adenosyl-L-Methionine (SAM-e) in its biologically active S/S enantiomer form. This supplement provides a preventative 400 mg dosage of SAM-e encapsulated in acid-resistant granules and capsules, alongside essential vitamins and a trace element crucial for its biosynthesis. SAM-e plays a key role in methylation processes, influencing DNA regulation, neurotransmitter synthesis, and mitochondrial function. It helps protect brain cells from degeneration, oxidative stress, and inflammation, contributing to healthier aging and improved cognitive function. As SAM-e is naturally produced in the liver, its synthesis declines with age, leading to DNA hypomethylation and mitochondrial dysfunction. The addition of Vitamin B12, Folic Acid, Vitamin B6, and Zinc enhances the effectiveness of SAM-e by supporting the methylation cycle, improving neuroprotection, and preventing oxidative damage. EBP® not only supports the prevention of neurodegenerative diseases such as Alzheimer’s and Parkinson’s, but also promotes optimal brain function, providing a holistic approach to maintaining mental and cellular health through epigenetic mechanisms.
EBP® – Epigenetic Brain Protector
A dietary supplement from Applied Epigenetics with the S/S-enantiomer, the only biologically active form of S-Adenosyl-L-Methionine, as a coated granulate and in gastro-resistant capsules, containing the vitamins and a trace element necessary for its biosynthesis, in a preventive 400 mg dosage.
EBP® – Epigenetic Brain Protector protects brain cells from cell death
S-Adenosylmethionine (SAM-e, Ademetionine) is an extremely important molecule that supports many biological functions in our body. It is closely involved in amino acid metabolism, DNA methylation, neurotransmitter synthesis, and liver function. Because of this, S-Adenosylmethionine (SAM-e, Ademetionine) is vital for general health and for specific therapeutic applications.
S-Adenosylmethionine (SAM-e, Ademetionine, AdoMet) is the sole methyl group donor for the DNA code
S-Adenosylmethionine (SAM-e) plays a central role as a methyl group donor in many biological processes, particularly in the methylation of molecules, which is crucial for cell function and gene regulation.
Methylation by S-Adenosylmethionine (SAM-e, Ademetionine):
DNA Methylation: DNA methylation is an essential epigenetic mechanism that regulates gene expression without changing the underlying DNA sequence. Here, SAM-e transfers its methyl group (–CH₃) to the DNA, especially at the cytosine of CpG sites. This methylation can “silence” genes or reduce their expression, which is important for processes like cell division, development, and response to environmental factors. Insufficient methylation can lead to problems such as the activation of tumor genes or the dysregulation of important genes.
Protein Methylation: Proteins can also be methylated by S-Adenosylmethionine (SAM-e, Ademetionine), affecting their function and interactions. This is particularly important for histones, which are proteins around which DNA is wrapped. Histone methylation can change chromatin structure and thus regulate access to DNA for transcription factors, influencing gene activity.
Lipid Methylation: S-Adenosylmethionine (SAM-e, Ademetionine) is involved in lipid methylation, which is crucial for the integrity and function of cell membranes, particularly for phospholipids. This methylation contributes to membrane stability and flexibility, impacting cell communication and division.
Neurotransmitter Synthesis: S-Adenosylmethionine (SAM-e, Ademetionine) also plays an important role in the synthesis of neurotransmitters such as serotonin, dopamine, and norepinephrine. These substances are vital for regulating mood, emotions, behavior, and other central functions. The methylation process enabled by SAM-e can influence the synthesis and activity of these neurotransmitters, which is of particular interest for treating depression and other mental disorders.
Mitochondria produce ATP (adenosine triphosphate), the energy currency of the cell, through the electron transport chain located in the inner mitochondrial membrane. The daily ATP production corresponds to our body weight!
The biosynthesis of S-Adenosylmethionine requires ATP for the formation of “active methionine” = ATP + Methionine (Cantoni, 1977).
Methionine Adenosyltransferase (MAT) is responsible for synthesizing S-Adenosylmethionine from methionine and ATP and is essential for maintaining methylation in somatic tissue, ensuring normal organism development, and being indispensable for cell survival.
Significance of Methylation:
Genetic Predisposition and Epigenetic Regulation: Methylation affects the genetic material without altering the DNA sequence. This means that environmental factors or dietary habits can activate or deactivate genes through changes in methylation patterns.
Development and Cell Division: Methylation controls which genes are active in a cell and which are not. This regulation is especially important during development and for cell growth.
Disease Prevention and Treatment: Disruption of the methylation cycle has been linked to various diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. An imbalance in methylation processes can also contribute to mental illnesses such as depression.
A crucial role of S-Adenosylmethionine (SAMe, Ademetionine) is its protection of mitochondria
S-Adenosylmethionine (SAM-e, Ademetionine) also plays an important role in protecting the mitochondria, the energy centers of our cells. Mitochondria are not only responsible for producing ATP (the energy source for cells), but also for many other cellular processes like regulating cell death (apoptosis) and metabolism. Protecting the mitochondria is crucial for maintaining cell health and preventing diseases associated with mitochondrial dysfunction, such as neurodegenerative diseases (e.g., Alzheimer’s, Parkinson’s) or metabolic disorders.
How does S-Adenosylmethionine protect mitochondria?
Antioxidant Effect: S-Adenosylmethionine (SAM-e, Ademetionine) has antioxidant properties that help protect mitochondria from damage by free radicals. Free radicals, especially in mitochondrial energy metabolism, can cause oxidative damage to cellular structures. This damage can lead to accelerated cell degradation and mitochondrial dysfunction. SAM-e protects the mitochondria by preventing the harmful effects of free radicals, especially by suppressing the overexpression of Monoamine Oxidase (MAO) at the gene locus.
Phospholipid Synthesis: S-Adenosylmethionine (SAM-e, Ademetionine) is crucial in synthesizing phospholipids, which are essential components of cell membranes, including mitochondrial membranes. Phospholipids like phosphatidylcholine are key to the structure and integrity of mitochondrial membranes. A healthy phospholipid metabolism ensures membrane stability and optimal mitochondrial function.
Methylation and Gene Regulation: As a methyl group donor, S-Adenosylmethionine (SAM-e, Ademetionine) is involved in the methylation of genes related to mitochondrial function and cell protection. By methylating genes in mitochondrial DNA or cellular signaling pathways, SAM-e influences gene expression, helping to activate or deactivate genes that are important for mitochondrial health. This includes genes involved in DNA repair, cell survival, and oxidative stress regulation, such as Monoamine Oxidase (MAO).
Support for Mitochondrial DNA: S-Adenosylmethionine (SAM-e, Ademetionine) supports the repair of DNA in mitochondria by participating in processes that fix mitochondrial DNA (mtDNA) damage. Mitochondria have their own DNA, which is vulnerable to oxidative stress. An effective repair mechanism is critical to maintaining mitochondrial function and helping cells cope with stressful conditions.
Reduction of Inflammation: Chronic inflammation can also damage mitochondria. S-Adenosylmethionine (SAM-e, Ademetionine) has anti-inflammatory properties and can reduce the production of pro-inflammatory molecules like cytokines. By reducing inflammation, SAM-e helps protect mitochondria from inflammation-related damage.
Mitochondrial Dysfunction and S-Adenosylmethionine (SAMe, Ademetionine):
Many diseases associated with mitochondrial dysfunction, such as neurodegenerative diseases (e.g., Alzheimer’s, Parkinson’s), musculoskeletal disorders (e.g., fibromyalgia), and metabolic disorders like diabetes mellitus, involve reduced mitochondrial function and increased free radical production.
In these cases, supporting mitochondrial health with S-Adenosylmethionine (SAM-e, Ademetionine) can play a therapeutic role by protecting mitochondria and maintaining their function.
Mitochondrial Dysfunction and DNA Hypomethylation in Alzheimer’s Disease (AD)
Mitochondrial dysfunction is an early event in Alzheimer’s disease (AD). The individual health prevention through the prevention of age-related S-Adenosylmethionine (SAM-e, Ademetionine) deficiency and its consequences has both personal and socio-medical significance.
Mitochondria carry Monoamine Oxidase B (MAOB) on their outer membrane, which, through oxidative deamination of neurotransmitters such as dopamine, serotonin, and norepinephrine, produces the highly reactive hydroxyl radical (•OH). This radical reacts with almost all surrounding macromolecules, like lipids, proteins, and DNA, causing oxidative damage to these cellular structures.
Methylation at the MAO gene locus prevents the overexpression of Monoamine Oxidase (MAO) and protects against cellular oxidative stress (ROS overload in mitochondria).
The EBP® – Epigenetic Brain Protector is made from naturally occurring substances in the body:
- Ademetionine (S-Adenosylmethionine, SAM-e)
- Vitamin B12
- Folic Acid
- Vitamin B6
- Zinc
Ademetionine (S-Adenosylmethionine): • Produced mainly in the liver, decreasing with age. • S-Adenosylmethionine deficiency leads to hypomethylation of DNA, causing diseases. We utilize ADOGRAN®, a coated granule of S-Adenosylmethionine, protecting its active form.
Vitamin B12: • Supports brain cell metabolism, maintaining normal nervous system and psychological functions. • Hydroxocobalamin in EBP® has the best depot effect in brain cells.
Folic Acid: • Contributes to amino acid synthesis, providing essential amino acid Methionine in the 1-carbon cycle. • Supports normal homocysteine metabolism, crucial for preventing hyperhomocysteinemia. • Essential for psychological function and immune system function. We use QUATREFOLIC®, the glucosamine salt of 5-Methyltetrahydrofolate, ensuring high bioavailability.
Vitamin B6: • Supports normal psychological function. • Contributes to normal homocysteine metabolism. • Reduces fatigue and tiredness. We use Vitamin B6 in its activated form, PYRIDOXAL-5-PHOSPHATE (P5P). Zinc: • Protects cells from oxidative stress, the primary cause of cellular aging. The combined action of Ademetionine, Hydroxocobalamin, QUATREFOLIC®, and Pyridoxal-5-Phosphate prevents an increase in blood homocysteine levels, crucial for physical and mental health safety.
In summary, the EBP® – Epigenetic Brain Protector is a comprehensive supplement designed to promote brain health and combat age-related issues by leveraging the power of applied epigenetics and naturally occurring substance.
Note: This information is provided for educational purposes and does not substitute for professional medical advice. Always consult with healthcare providers for personalized guidance on health-related matters.
Copyright © Eduard Rappold 2025
