Dietary Supplement

SAM-e 100% Active 400 mg / Capsule

30 Capsules

S-Adenosylmethionine as S/S enantiomer pure SAM-e with 54.10% SAM-e – ION


Together with ATP (cellular energy form), it ranks among the most important molecules in our metabolism.

It’s an innovative product awarded with a gold medal:

“We need leaps in innovation that significantly improve the lives and health of as many people as possible.”

Meaningful and purposeful benefits are found when we focus on addressing human needs with a mission that pushes the boundaries of what’s possible, enhancing fundamental aspects of life.


SAM-e 100% Active 400 mg / Capsule

by NUGENIS establishes a successful concept with a unique feature, setting the product apart from competitors.


The selection and production of NUGENIS products are carried out with utmost care:

purely plant-based, GMO-free, kosher, and halal,

free from gluten, lactose, and fructose.


SAM-e regulates key functions

SAM-e is involved in several important biological reactions, either as a methyl group donor or as an enzymatic inductor, acting as a cofactor where SAM-e is required.

The S-Adenosylmethionine (SAM-e 100% active) biosynthesis decreases early in adulthood and requires regular SAM-e 100% active supplementation to ensure benefits for the organism.


What makes SAM-e 100% Active special?

SAM-e 100% Active 400 mg / Capsule from NUGENIS contains double the dosage of enantiomerically pure 96% (S/S) – S-Adenosyl-L-Methionine with 54.10% SAM-e – ION, providing maximum biological effect.


SAM-e exists in two diastereoisomeric forms:

Only the (S/S) isomer as the bioactive form has 100% biological efficacy.

The biosynthesis of S-Adenosylmethionine in the body exclusively produces (S)-S-Adenosylmethionine as the (S/S)-enantiomer of SAM-e.


DANGER: In contrast, the (R/S) enantiomer of SAM-e

The configuration change from (S) to (R) leads to inhibition of methyltransferase activity. The (S)-enantiomer of SAM-e is the active enantiomer and serves as a methyl group donor for various methylation reactions in the body. In contrast, the (R)-enantiomer inhibits methyltransferase activity, thus affecting methylation processes, including DNA methylation.

DNA methylation is an important epigenetic mechanism that regulates gene expression. Disruption of this process by the (R)-enantiomer of SAM-e can lead to altered gene expression, which in turn is associated with various diseases and premature aging.


DOSAGE RECOMMENDATION: Take one capsule per day with 200 ml of liquid before a meal. Optimal preventive daily dosage 1 x 1 / capsule. The recommended daily dose should not be exceeded.

STORAGE INFORMATION: Store at refrigerator temperature of 5°C – 7°C, dry, and protected from light. Keep the container tightly closed after use.


IMPORTANT NOTES: Not suitable for persons under 18 years of age, pregnant or breastfeeding women. Keep out of reach of small children. Dietary supplements are not a substitute for a varied and balanced diet, which is important in conjunction with a healthy lifestyle.

INGREDIENTS: S-Adenosyl-L-Methionine

Separating agent: microcrystalline cellulose

Coating agent: Hydroxypropylmethylcellulose,

CONTENT (1 CAPSULE = Daily dose)

(S/S) – S-Adenosyl-L-Methionine 400 mg

CONTENT: 30 capsules, vegan, enteric-coated, titandioxid-free

NET WEIGHT: 18 g ℮

Also available in all Austrian pharmacies and in Germany.


Note: These informations are provided for educational purposes and do not replace professional medical advice. Always consult healthcare providers for individual guidance on health-related issues.