Cellular Renewal Support from Wheat Germ Extract

NUGENIS Spermidine 3 mg Capsules provide a defined daily amount of spermidine derived from wheat germ extract—one of the richest natural dietary sources of this important polyamine.

Spermidine is a naturally occurring molecule found in plants, microbes, and human cells. It plays a central role in cellular maintenance processes including autophagy, protein quality control, and mitochondrial renewal.

60 capsules per bottle | 3 mg spermidine per capsule | 60-day supply

Why Spermidine Matters

Spermidine is part of a highly conserved biological system that supports cellular homeostasis and renewal.

Due to its positive charge, spermidine interacts with DNA, RNA, and proteins, helping stabilize cellular structures and regulate key metabolic pathways.

Research suggests that spermidine influences:

• cellular growth and differentiation
• chromatin organization and epigenetic regulation
• autophagy and mitophagy
• protein synthesis and proteostasis

Rather than acting as a single-target molecule, spermidine supports coordinated cellular maintenance processes.

(Eisenberg et al., 2009; Madeo et al., 2018)

A Key Process: Autophagy

One of the most studied biological effects of spermidine is its ability to support autophagy, a cellular recycling and quality-control mechanism.

Autophagy helps cells:

• remove damaged proteins
• recycle cellular components
• eliminate dysfunctional mitochondria
• maintain energy efficiency

Mechanistically, spermidine has been associated with modulation of pathways involving:

• EP300 inhibition
• AMPK activation
• SIRT1 signaling
• induction of autophagy-related genes

(Eisenberg et al., 2009; Morselli et al., 2011)

Autophagy functions as a fundamental system for cellular renewal and stress resilience.

From SAM-e to Spermidine

Polyamine Metabolism

Spermidine is produced in the body through the polyamine metabolic pathway, which originates from S-adenosylmethionine (SAM-e).

Simplified pathway:

SAM-e → decarboxylated SAM-e → aminopropyl transfer → spermidine → spermine

Because of this relationship, polyamine metabolism intersects with:

• methylation pathways
• cellular redox balance
• metabolic regulation
• autophagic recycling

(Mato & Corrales, 2010)

Spermidine, Nutrition, and the Microbiome

Spermidine occurs naturally in a variety of foods, especially plant-based sources.

Dietary sources include:

• wheat germ
• soybeans
• legumes
• mushrooms
• aged cheese
• green leafy vegetables

In addition, several gut microbes are capable of producing or metabolizing polyamines, meaning that diet, microbiome activity, and intestinal absorption together influence systemic spermidine availability.

Recent research also highlights the role of spermidine in plant stress adaptation, linking agricultural resilience with nutritional health benefits.

(Blagojević et al., 2026)

Spermidine and Healthy Aging

Experimental models have shown that spermidine can influence cellular maintenance pathways associated with longevity biology.

In human observational studies, higher dietary spermidine intake has been associated with:

• lower cardiovascular mortality
• improved metabolic health markers
• better cognitive performance

These associations are thought to relate to:

• maintenance of autophagic activity
• mitochondrial quality control
• reduction of chronic inflammatory signaling
• improved cellular stress resilience

(Kiechl et al., 2018)

Observational associations do not establish causality but support the biological relevance of spermidine in healthy aging research.

Why Wheat Germ Extract?

Among natural foods, wheat germ is one of the most concentrated dietary sources of spermidine.

During germination, plant cells produce high levels of polyamines to support rapid cellular growth and development.

This makes wheat germ extract an ideal plant-derived source for spermidine supplementation.

NUGENIS Spermidine 3 mg

Product Overview

Active Ingredient

Spermidine derived from wheat germ extract

Per Capsule

3 mg spermidine

Bottle

60 capsules

Supply

60 days (1 capsule daily)

Suggested Use

Take 1 capsule daily with water, preferably with a meal.

Who May Consider Spermidine?

Adults interested in supporting:

• cellular renewal processes
• autophagy-related maintenance pathways
• metabolic and mitochondrial health
• healthy aging strategies

Spermidine at a Glance

Mechanisms associated in research

• modulation of EP300
• activation of AMPK and SIRT1 pathways
• induction of autophagy-related genes
• support of mitochondrial quality control

Biological processes influenced

• protein quality control (proteostasis)
• oxidative stress regulation
• cellular stress resilience
• maintenance of metabolic balance

Scientific Perspective

Spermidine represents an evolutionarily conserved regulator of cellular maintenance. It connects several biological systems including methylation metabolism, redox regulation, autophagy, and mitochondrial renewal.

Research in aging biology increasingly recognizes polyamine metabolism as an important component of cellular health and resilience.

Important Notice

This product is a dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease.

Statements on this page reflect scientific research on biological mechanisms and nutritional associations and have not been evaluated by the U.S. Food and Drug Administration.

Dietary supplements should not replace a balanced diet and healthy lifestyle.

References

Blagojević, B. D., Brunel-Muguet, S., Šućur, R., et al. (2026).
The role of spermidine in plants and humans: A pathway from climate change adaptation to health benefits. npj Science of Food.

Eisenberg, T., et al. (2009).
Induction of autophagy by spermidine promotes longevity. Nature Cell Biology.

Kiechl, S., et al. (2018).
Higher spermidine intake is linked to reduced mortality in humans. American Journal of Clinical Nutrition.

Madeo, F., et al. (2018).
Spermidine in health and disease. Science.

Mato, J. M., & Corrales, F. J. (2010).
S-adenosylmethionine metabolism and polyamine biosynthesis.

Morselli, E., et al. (2011).
Autophagy induction by spermidine through EP300 inhibition.