NUGENIS – DR. EDUARD RAPPOLD, MSc

Platelets mirror changes in the frontal lobe antioxidant system in Alzheimer’s disease.

Huriye Ercan,  Christina Maria Reumiller,  Jacqueline Mühlberger,  Felicia Hsu,  Georg Johannes Schmidt,  Ellen Umlauf,  Ingrid Miller,  Eduard Rappold,  Johannes Attems,  Rudolf Oehler,  Maria Zellner

Alzheimer’s Dement. 2025; 21:e70117. https://doi.org/10.1002/alz.70117

Rappold, E., Kratochvila, H.G. (2024). Das Darm-Mikrobiom, Epigenetik und Spermidin – Wechselwirkungen mit klinischer Relevanz. In: OM & Ernährung, Sonderheft 34, S. 78–83.

Therapeutics That Can Potentially Replicate or Augment the Anti-Aging Effects of Physical Exercise
Adriana De Sousa Lages, Valentim Lopes, João Horta, João Espregueira-Mendes, Renato Andrade and Alexandre Rebelo-Marques [Zum Artikel]

Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer’s disease mouse model
Kiara Freitag, Nele Sterczyk, Sarah Wendlinger, Benedikt Obermayer, Julia Schulz, Vadim Farztdinov, Michael Mülleder, Markus Ralser, Judith Houtman, Lara Fleck, Caroline Braeuning, Roberto Sansevrin, Christian Hoffmann, Dragomir Milovanovic, Stephan J. Sigrist, Thomas Conrad, Dieter Beule, Frank L. Heppner, and Marina Jendrach [Zum Artikel]

Spermidine-mediated hypusination of translation factor EIF5A improves mitochondrial fatty acid oxidation and prevents non-alcoholic steatohepatitis progression
Jin Zhou, Jeremy Pang, Madhulika Tripathi, Jia Pei H,Anissa Anindya Widjaja, Shamini Guna Shekeran, Stuart Alexander Cook, Ayako Suzuki, Anna Mae Diehl ,Enrico Petretto , Brijesh Kumar Singh1 & Paul Michael Yen [Zum Artikel]

Gender-related increase of tropomyosin-1 abundance in platelets of Alzheimer’s disease and mild cognitive impairment patients
Reumiller, CM., Schmidt, GJ., Dharami, I., Umlauf, E., Rappold, E., Zellner, M.
Journal of Proteomics (2017) (epub ahead of print) [Zum Artikel]

Careful neuropsychological testing reveals a novel genetic marker, GSTO1*C, linked to the pre-stage of Alzheimer’s disease
Umlauf,E., Rappold, E., Schiller, B., Fuchs, P., Rainer, M., Wolf, B., Zellner, M.
Oncotarget 7 (26) (2016) [Zum Artikel]

A platelet protein biochip rapidly detects an Alzheimer’s disease-specific phenotype
Veitinger, M., Oehler, R., Umlauf, E., Baumgartner, R., Schmidt, G., Gerner, Ch., Babeluk, R., Attems, J., Mitulović, G., Rappold, E., Lamont, J., Zellner, M.
Acta Neuropathologica 128(5) (2014) [Zum Artikel]

Gender-related increase of tropomyosin-1 abundance in platelets of Alzheimer’s disease and mild cognitive impairment patients
Reumiller, CM., Schmidt, GJ., Dharami, I., Umlauf, E., Rappold, E., Zellner, M.
Journal of Proteomics (2017) (epub ahead of print) [Zum Artikel]

Careful neuropsychological testing reveals a novel genetic marker, GSTO1*C, linked to the pre-stage of Alzheimer’s disease
Umlauf,E., Rappold, E., Schiller, B., Fuchs, P., Rainer, M., Wolf, B., Zellner, M.
Oncotarget 7 (26) (2016) [Zum Artikel]

A platelet protein biochip rapidly detects an Alzheimer’s disease-specific phenotype
Veitinger, M., Oehler, R., Umlauf, E., Baumgartner, R., Schmidt, G., Gerner, Ch., Babeluk, R., Attems, J., Mitulović, G., Rappold, E., Lamont, J., Zellner, M.
Acta Neuropathologica 128(5) (2014) [Zum Artikel]

Impact of Ademetionine Disulfate Tosylate /Vitamin B12 therapy on cognition in Alzheimer’s Disease and related biomarkers
Rappold E.
Master-These an der Donau-Universität Krems (2014)

Identification and validation of platelet low biological variation proteins, superior to GAPDH, actin and tubulin, as tools in clinical proteomics
Baumgartner, R., Umlauf, E., Veitinger, M., Guterres, S., Rappold, E., Babeluk, R., Mitulović, G., Oehler, R., Zellner, M.
Journal of proteomics 94C:540-551 (2013) [Zum Artikel]

Comparative platelet proteome analysis reveals an increase of monoamine oxidase-B protein expression in Alzheimer’s disease but not in non-demented Parkinson’s disease patients
Zellner; M. , Baureder, M., Rappold, E., Bugert, P., Kotzailias, N., Babeluk, R., Baumgartner, R., Attems, J., Gerner, Ch., Jellinger, K., Roth, E., Oehler, R., Umlauf, E.·
Journal of proteomics 75(7):2080-92 (2012) [Zum Artikel]

Langzeiternährungstherapie einer hochbetagten Seniorin. Positive Effekte durch die Gabe von Sondennahrung auf Basis von Lebensmittel
Rappold, E. ·
focus neurogeriatrie 3(1):16-20 (2009)

Biological Variation of the Platelet Proteome in the Elderly Population and Its Implication for Biomarker Research
Winkler, W., Zellner, M., Diestinger, M., Babeluk, R., Marchetti, M., Goll, A., Zehetmayer, S., Bauer, P., Rappold, E., Miller, I., Roth, E., Allmaier, G., Oehler, R. ·
Molecular & Cellular Proteomics 7(1):193-203 (2008) [Zum Artikel]

Aspekte der künstlichen Ernährung bei demenzkranken Patienten in der Geriatrie
Rappold, E., Kratochvila, H. G.
Ethik in der Medizin 16(3):253-264 (2004)

Downregulation of carnitine acyltransferases and organic cation transporter OCTN2 in mononuclear cells in healthy elderly and patients with myelodysplastic syndromes
Karlic, H., Lohninger, G., Laschan, C., Lapin, A., Böhmer, F., Huemer, M., Guthann, E., Rappold, E., Pfeilstöcker, M.
Journal of Molecular Medicine 81(7):435-42 (2003) [Zum Artikel]

Treatment of polymorphous light eruption with nicotinamide: a pilot study
Neumann, R., Rappold, E., Pohl-Markl, H.
British Journal of Dermatology 115(1):77-80 (1986) [Zum Artikel]

Die nachfolgende Literaturliste dokumentiert die wissenschaftlichen Grundlagen der Epigenetik (2026).

Sie umfasst zentrale Arbeiten zur Molekularbiologie und Epigenetik, klinische Studien, translational orientierte Forschung sowie Beiträge aus angrenzenden Disziplinen wie Neurowissenschaften, Stoffwechselbiologie, Onkologie, Psychoneuroimmunologie und Gesundheitswissenschaften.

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